Virtual Reality Cognitive-Affective Training for Opioid Use Disorder- A Phase 2 RCT

Description

The goal of this clinical trial is to examine the usefulness of a virtual reality-delivered intervention for individuals with opioid use disorder who are taking medication. The main question it aims to answer is will people with opioid use disorder who receive the study intervention, Mindfulness-Oriented Recovery Enhancement in Virtual Reality (MORE-VR), have fewer days in which they use opioids than will people who just receive their usual treatment. Participants will be randomly assigned to either receive 8 weekly sessions of MORE-VR in addition to their usual treatment, or treatment as usual only. Researchers will compare these groups at the end of treatment and three months after treatment is over on number of days of opioid use and time until first opioid use lapse, as well as drug craving and mood.

Conditions

Opioid Use Disorder

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to examine the usefulness of a virtual reality-delivered intervention for individuals with opioid use disorder who are taking medication. The main question it aims to answer is will people with opioid use disorder who receive the study intervention, Mindfulness-Oriented Recovery Enhancement in Virtual Reality (MORE-VR), have fewer days in which they use opioids than will people who just receive their usual treatment. Participants will be randomly assigned to either receive 8 weekly sessions of MORE-VR in addition to their usual treatment, or treatment as usual only. Researchers will compare these groups at the end of treatment and three months after treatment is over on number of days of opioid use and time until first opioid use lapse, as well as drug craving and mood.

Digital Therapeutic Development of Virtual Cognitive-Affective Training for Opioid Use Disorder: A Phase 2 Randomized Controlled Trial

Virtual Reality Cognitive-Affective Training for Opioid Use Disorder- A Phase 2 RCT

Condition
Opioid Use Disorder
Intervention / Treatment

-

Contacts and Locations

Salt Lake City

University of Utah, Salt Lake City, Utah, United States, 84112

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 years of age or older
  • * current DSM-5 OUD diagnosis
  • * prescribed medications for opioid use disorder (e.g., buprenorphine, methadone)
  • * completion of a standardized mindfulness intervention (e.g., MORE, MBRP, MBSR)
  • * active psychosis or suicidality
  • * reports, or is noted by clinical or study staff as showing cognitive impairment
  • * condition which might be contraindicated for VR use including seizure disorder, vertigo, severe motion sickness, recent concussion

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

BehaVR LLC,

Risa Weisberg, PhD, PRINCIPAL_INVESTIGATOR, BehaVR LLC

Study Record Dates

2026-05