Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

Description

We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.

Conditions

Hyperglycaemia (Non Diabetic), Prediabetes

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Study Overview

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Study Details

Study overview

We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.

Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

Condition
Hyperglycaemia (Non Diabetic)
Intervention / Treatment

-

Contacts and Locations

Little Rock

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States, 72205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 1. Males and females ages 40-60 years.
  • * 2. BMI 25 to \<35 kg/m2.
  • * 3. Capable of providing informed consent.
  • * 4. COVID-19 negative and/or asymptomatic.
  • * 5. Willing to abstain from drinking alcohol or consuming marijuana and CBD products during the 4-day study meal period
  • * 6. HbA1c: 5.7-6.4%
  • * 1. Participant who does not/will not eat animal protein sources.
  • * 2. Allergy to wheat, soy, or common ingredients in plant-based protein products.
  • * 3. Body mass index \<25 kg/m2 or \>35 kg/m2.
  • * 4. Hemoglobin \<10g/dL at screening.
  • * 5. Platelets \<150,000/uL at screening.
  • * 6. History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.
  • * 7. History of gastrointestinal bypass/reduction surgery.
  • * 8. Pregnant or lactating individuals.
  • * 9. History of a chronic inflammatory disease (e.g. Lupus, Crohn's disease)
  • * 10. Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.
  • * 11. Currently using prescription blood thinning medications.
  • * 12. Currently using corticosteroid medications (cortisone, hydrocortisone, prednisone, etc.).
  • * 13. Unable or unwilling to suspend aspirin use for 7 days prior to Visit 3.
  • * 14. Unwilling to avoid using protein or amino-acid supplements during participation.
  • * 15. Unwilling to fast overnight.
  • * 16. Unwilling to avoid alcohol, marijuana and CBD products for the four study days.
  • * 17. Participating in \>200 minutes/week of vigorous exercise and/or \>4 days/week of resistance training.

Ages Eligible for Study

40 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Arkansas,

David Church, PhD, PRINCIPAL_INVESTIGATOR, University of Arkansas

Study Record Dates

2026-06-01