RECRUITING

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis

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Conditions

Progressive Pulmonary FibrosisBMS-986278LPA1 antagonistPulmonary fibrosisInterstitial lung diseaseRheumatoid ArthritisConnective Tissue DisordersSarcoidosisSclerodermaFibrosisAntifibrotic therapy

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986278 in Participants with Progressive Pulmonary Fibrosis.

Official Title

A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis

Quick Facts

Study Start:2023-10-25
Study Completion:2027-12-27
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06025578

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
855-907-3286
Clinical.Trials@bms.com
First line of the email MUST contain the NCT# and Site #.
CONTACT

Principal Investigator

Bristol-Myers Squibb
STUDY_DIRECTOR
Bristol-Myers Squibb

Study Locations (Sites)

The University of Alabama at Birmingham
Birmingham, Alabama, 35294
United States
Local Institution - 0416
Phoenix, Arizona, 85012-2369
United States
St. Joseph's Hospital and Medical Center
Phoenix, Arizona, 85013-4220
United States
Local Institution - 0526
Tucson, Arizona, 85723-3001
United States
Local Institution - 0336
La Jolla, California, 92037-1027
United States
Local Institution - 0066
La Jolla, California, 92093
United States
University of Southern California (USC) - Keck School of Medicine (KSOM) - Transplant Clinic
Los Angeles, California, 90033-5313
United States
David Geffen School of Medicine at UCLA
Los Angeles, California, 90095-3075
United States
UC Irvine Medical Center
Orange, California, 92868-3201
United States
University of California UC Davis Medical Center
Sacramento, California, 95817
United States
University of California, San Francisco Medical Center- Pulmonary Practice
San Francisco, California, 94143-2202
United States
Stanford Hospital and Clinics
Stanford, California, 94305
United States
University of Colorado Anschutz Medical Campus - Department of Family Medicine
Aurora, Colorado, 80045
United States
National Jewish Health
Denver, Colorado, 80206
United States
Yale New Haven Hospital
New Haven, Connecticut, 06510
United States
Stamford Health Medical Group - Stamford - 29 Hospital Plaza Suite 605
Stamford, Connecticut, 06902-3602
United States
Christiana Care Pulmonary Associates - Newark
Newark, Delaware, 19713-1337
United States
Medstar Georgetown University Hospital
Washington, District of Columbia, 20007-2113
United States
Meris Clinical Research
Brandon, Florida, 33511-5706
United States
Florida Lung, Asthma and Sleep Specialists - Celebration
Celebration, Florida, 34747-1818
United States
St Francis Sleep Allergy & Lung Institute
Clearwater, Florida, 33765
United States
Omega Research Consultants LLC
DeBary, Florida, 32713-1817
United States
Malcom Randall VA Medical Center
Gainesville, Florida, 32608
United States
University of Florida (UF) Health Shands Hospital
Gainesville, Florida, 32610
United States
Pulmonary Specialists of the Palm Beaches
Loxahatchee Groves, Florida, 33411
United States
Local Institution - 0347
Miami, Florida, 33125-1624
United States
Local Institution - 0517
Miami, Florida, 33136-1124
United States
Local Institution - 0220
Ocala, Florida, 34470
United States
Avanza Medical Research Center
Pensacola, Florida, 32504
United States
Coastal Pulmonary & Critical Care, P.L.C.
Saint Petersburg, Florida, 33704
United States
Tampa General Hospital
Tampa, Florida, 33601-1289
United States
Local Institution - 0378
Weston, Florida, 33331-3609
United States
Emory Clinic
Atlanta, Georgia, 30322-1013
United States
Local Institution - 0465
Austell, Georgia, 30106-1110
United States
Pulmonology, Sleep, Asthma & Allergy Center of Dublin
Dublin, Georgia, 31021-2561
United States
Northwestern Memorial Hospital
Chicago, Illinois, 60611
United States
Local Institution - 0346
Chicago, Illinois, 60612-3841
United States
Local Institution - 0023
Chicago, Illinois, 60637-1447
United States
Local Institution - 0040
Evanston, Illinois, 60201-1779
United States
Loyola University Health System
Maywood, Illinois, 60153-3328
United States
Local Institution - 0441
Indianapolis, Indiana, 46202-1252
United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, 522242-1009
United States
University of Kansas Medical Center (KUMC)
Kansas City, Kansas, 66103-2937
United States
Local Institution - 0045
Louisville, Kentucky, 40207-4652
United States
Norton Healthcare, Inc.
Louisville, Kentucky, 40218-2497
United States
University of Maryland - Marlene and Stewart Greenebaum Cancer Center
Baltimore, Maryland, 21201-1544
United States
Local Institution - 0033
Towson, Maryland, 21204-7700
United States
Massachusetts General Hospital
Boston, Massachusetts, 02114-2621
United States
Steward St. Elizabeth Medical Center
Boston, Massachusetts, 02135-2907
United States
Local Institution - 0069
Boston, Massachusetts, 02215
United States
Local Institution - 0079
Springfield, Massachusetts, 01199-1002
United States
University of Michigan Health System - A. Alfred Taubman Health Care Center - Pulmonary Clinic
Ann Arbor, Michigan, 48109-5000
United States
Local Institution - 0031
Detroit, Michigan, 48202
United States
Spectrum Health Medical Group Pulmonary
Grand Rapids, Michigan, 49546-8293
United States
Local Institution - 0509
Royal Oak, Michigan, 48073-6712
United States
M Health Fairview University of Minnesota Medical Center - CSC - Center for Lung Science and Health
Minneapolis, Minnesota, 55455-4800
United States
The Lung Research Center
Chesterfield, Missouri, 63017
United States
Washington University School of Medicine in St. Louis
Saint Louis, Missouri, 63110-1010
United States
Local Institution - 0525
Reno, Nevada, 89502-1576
United States
Local Institution - 0371
Newark, New Jersey, 07112-2027
United States
Northern Westchester Hospital
Mount Kisco, New York, 10549-3417
United States
Local Institution - 0503
New York, New York, 10027
United States
Icahn School of Medicine at Mount Sinai
New York, New York, 10029-6574
United States
Duke University Medical Center
Durham, North Carolina, 27710
United States
Accellacare US Inc. of Wilmington
Wilmington, North Carolina, 28401-7307
United States
Southeastern Research Center
Winston-Salem, North Carolina, 27103
United States
University of Cincinnati College Of Medicine
Cincinnati, Ohio, 45267
United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106
United States
The Ohio State University Wexner Medical Center
Columbus, Ohio, 43201
United States
Mercy St. Vincent Medical Center
Toledo, Ohio, 43608-2603
United States
OU Health Sciences Center - OU Health Physicians - Cardiology, Pulmonary & Vascular Medicine Clinic
Oklahoma City, Oklahoma, 73104-5417
United States
Layrek Clinical Research
Tulsa, Oklahoma, 74133
United States
Oregon Health & Science University - Pulmonary Clinic
Portland, Oregon, 97239-3011
United States
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-2360
United States
Penn Medicine - Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, 19104-5161
United States
Thomas Jefferson University Hospital - Jane and Leonard Korman Lung Center
Philadelphia, Pennsylvania, 19107-5109
United States
Temple University Hospital (TUH) - Temple Lung Center (TLC)
Philadelphia, Pennsylvania, 19140-5103
United States
Local Institution - 0466
Pittsburgh, Pennsylvania, 15213
United States
Pulmonology Associates - Wynnewood
Wynnewood, Pennsylvania, 19096
United States
Medical University of South Carolina- College of Medicine
Charleston, South Carolina, 29425
United States
Velocity Clinical Research - Durham
Greenville, South Carolina, 29615
United States
Local Institution - 0469
Rock Hill, South Carolina, 29732-1160
United States
Vanderbilt Lung Institute - One Hundred Oaks
Nashville, Tennessee, 37204
United States
Local Institution - 0356
Nashville, Tennessee, 37205-2287
United States
Local Institution - 0024
Dallas, Texas, 75235-5351
United States
Baylor University Medical Center at Dallas
Dallas, Texas, 75246
United States
Baylor College of Medicine Medical Center - Pulmonary, Critical Care, and Sleep Medicine
Houston, Texas, 77030-4202
United States
McGovern Medical School - UT Physicians - Pulmonary Medicine - Texas Medical Center Location
Houston, Texas, 77030
United States
Metroplex Pulmonary and Sleep Center
McKinney, Texas, 75069
United States
The University of Texas Health San Antonio Medical Arts & Research Center
San Antonio, Texas, 78229-3931
United States
University of Utah, University Hospital
Salt Lake City, Utah, 84108
United States
Local Institution - 0504
Burlington, Vermont, 05405-1742
United States
Local Institution - 0505
Falls Church, Virginia, 22042
United States
VCU Medical Center
Richmond, Virginia, 23298-5002
United States
Western Washington Medical Group (WWMG) - Everett - Silver Lake Medical Center Location
Everett, Washington, 98208-6526
United States
University of Washington Medical Center
Seattle, Washington, 98195
United States
Local Institution - 0395
Milwaukee, Wisconsin, 53226-3522
United States

Collaborators and Investigators

Sponsor: Bristol-Myers Squibb

  • Bristol-Myers Squibb, STUDY_DIRECTOR, Bristol-Myers Squibb

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-10-25
Study Completion Date2027-12-27

Study Record Updates

Study Start Date2023-10-25
Study Completion Date2027-12-27

Terms related to this study

Keywords Provided by Researchers

  • BMS-986278
  • LPA1 antagonist
  • Pulmonary fibrosis
  • Interstitial lung disease
  • Rheumatoid Arthritis
  • Connective Tissue Disorders
  • Sarcoidosis
  • Scleroderma
  • Fibrosis
  • Antifibrotic therapy

Additional Relevant MeSH Terms

  • Progressive Pulmonary Fibrosis