RECRUITING

The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to test the effects of MitoQ supplementation in older adults and frail older adults with physical dysfunction and/or cognitive dysfunction. The main question\[s\] it aims to answer are: * To compare vascular function, oxidative stress levels, and physical and cognitive function among older adults and frail older adults with physical and cognitive dysfunction * To determine whether MitoQ supplementation has the potential to improve vascular function in central and cerebral vessels * To determine whether MitoQ supplementation can enhance physical and cognitive capabilities.

Official Title

The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults

Quick Facts

Study Start:2024-09-26

Study Completion:2027-07-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06027554

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 80 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* men and women aged 65-80 with a slow gait speed (0.4m/s based on a 4m walk) and/or mild cognitive impairment. * good cardiovascular health (not taking any blood pressure/flow/metabolism altering medications)	* A vaccination in past two weeks * Recent acute infection three weeks prior to enrollment * Known immunodeficiency (including HIV infection, primary immunodeficiency, any history of chemotherapy or radiotherapy * Use of medicines during past 6 months known to alter immune response such as high- dose corticosteroids * Severe autoimmune disease requiring biological therapy * Major severe illness and/or Hospitalization in past 3 months * On warfarin or other medications that are considered a blood thinner * Recent fall or other conditions that will impair ability to complete and/or interpret mobility performance test * Known bleeding disorder * Any conditions that would impair the function to perform grip strength test * include advanced neurological disease, severe co-morbid disease, terminal illness with reduced life expectancy, severe disability, unintentional weight loss in last 12 months and participation in another study. * Diabetes patients requiring insulin (For reducing the risk that participants will have hypoglycemic episodes when fasting for study visits) * Baseline ECG QTc \>450 ms in men and QTc \>460 ms in women * Prior diagnosis of ventricular arrhythmia (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes)

Inclusion Criteria

Exclusion Criteria

* men and women aged 65-80 with a slow gait speed (0.4m/s based on a 4m walk) and/or mild cognitive impairment.
* good cardiovascular health (not taking any blood pressure/flow/metabolism altering medications)

* A vaccination in past two weeks
* Recent acute infection three weeks prior to enrollment
* Known immunodeficiency (including HIV infection, primary immunodeficiency, any history of chemotherapy or radiotherapy
* Use of medicines during past 6 months known to alter immune response such as high- dose corticosteroids
* Severe autoimmune disease requiring biological therapy
* Major severe illness and/or Hospitalization in past 3 months
* On warfarin or other medications that are considered a blood thinner
* Recent fall or other conditions that will impair ability to complete and/or interpret mobility performance test
* Known bleeding disorder
* Any conditions that would impair the function to perform grip strength test
* include advanced neurological disease, severe co-morbid disease, terminal illness with reduced life expectancy, severe disability, unintentional weight loss in last 12 months and participation in another study.
* Diabetes patients requiring insulin (For reducing the risk that participants will have hypoglycemic episodes when fasting for study visits)
* Baseline ECG QTc \>450 ms in men and QTc \>460 ms in women
* Prior diagnosis of ventricular arrhythmia (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes)

Contacts and Locations

Principal Investigator

Oh Sung Kwon, PhD

PRINCIPAL_INVESTIGATOR

University of Connecticut

Study Locations (Sites)

UConn Health

Farmington, Connecticut, 06030

United States

Collaborators and Investigators

Sponsor: UConn Health

Oh Sung Kwon, PhD, PRINCIPAL_INVESTIGATOR, University of Connecticut

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-09-26

Study Completion Date2027-07-01

Study Record Updates

Study Start Date2024-09-26

Study Completion Date2027-07-01

Terms related to this study

Additional Relevant MeSH Terms

Frailty
Mild Cognitive Impairment
Aging