RECRUITING

Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine. Specifically, the investigators will be evaluating ease of laryngoscopy, vocal cord view, vocal cord opening, and movement of limbs and coughing during tracheal intubation in order to assess intubation conditions, to compare efficiency and success rate of tracheal intubation between two induction agents and to determine the rate of patient awareness during induction and post-operative recall of paralysis.

Official Title

Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine : A Prospective Non-inferiority Randomized and Blind Trial

Quick Facts

Study Start:2023-09-13
Study Completion:2024-09-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06029049

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * BMI \> 30kg/m2 or Mallampati class III or IV.
  2. * Requiring general anesthesia and endotracheal intubation
  1. * Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease(COPD) and asthma.
  2. * The American Society of Anesthesiologists (ASA) physical status classification \> III.
  3. * Patients requiring awake intubation.
  4. * Pregnant women.
  5. * Untreated ischemic heart disease.
  6. * Patients requiring an induction dose of propofol \< 1 mg/kg.
  7. * Allergy to propofol, rocuronium, succinylcholine, or sugammadex.
  8. * Patients with renal failure and unknown potassium (K+) level, or patients with K+ level \> 5.0
  9. * Personal history of malignant hyperthermia (MH), or family history of MH
  10. * Patients with suspected or diagnosed neuromuscular disease, patients with burn injuries

Contacts and Locations

Study Contact

Lauren M Nakazawa, MD,MBA
CONTACT
713-500-6775
Lauren.M.Nakazawa@uth.tmc.edu
Ellie Tuchaai
CONTACT
713.614.9355
Ellie.J.Tuchaai@uth.tmc.edu

Principal Investigator

Lauren M Nakazawa, MD,MBA
PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center, Houston

Study Locations (Sites)

The University of Texas Health Science Center at Houston
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center, Houston

  • Lauren M Nakazawa, MD,MBA, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center, Houston

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-09-13
Study Completion Date2024-09-12

Study Record Updates

Study Start Date2023-09-13
Study Completion Date2024-09-12

Terms related to this study

Additional Relevant MeSH Terms

  • Anesthesia