RECRUITING

Cerebrovascular Health and Resilience in Midlife

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Conditions

Psychological StressCardiovascular DiseasesCerebrovascular Disorders

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study examines cardiovascular responses to a brief psychological challenge under laboratory conditions among adult volunteers. The study volunteers are asked to complete two study sessions. In one session, the volunteers are asked to provide demographic and health-related information via questionnaires and an interview. In that session, volunteers would then be asked to undergo evaluations of their body composition, blood pressure, heart rate, and other signs of cardiovascular function and health. Lastly, volunteers would be asked to take part in a brief and challenging psychological task after a period of rest while cardiovascular activity is measured. In the other session, volunteers are asked to undergo magnetic resonance imaging and to complete neuropsychological tests of memory, attention, and processing speed. In addition to these two sessions, volunteers are asked to complete online questionnaires. The study is designed to examine associations between transient changes in cardiovascular activity induced by the psychological task, measures of overall cardiovascular health, and measures of cerebrovascular health measured by magnetic resonance imaging. Study results are expected to provide new information about the relationships between cardiovascular activity changes to psychological challenges and cardiovascular and cerebrovascular health in adults.

Official Title

Cerebrovascular Health and Resilience in Midlife

Quick Facts

Study Start:2023-10-17
Study Completion:2029-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06029348

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 59 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Able to attend 2 study visits at the University of Pittsburgh campus in Oakland (Pennsylvania)
  2. * Able to read and speak English
  1. * Uncontrolled hypertension (systolic blood pressure \>160 or diastolic blood pressure \>100 mmHg)
  2. * Current use of anticonvulsant, anti-Parkinson, neuroleptic, or antipsychotic medications
  3. * Current use of glucocorticoids (e.g., oral prednisone) or ephedrine
  4. * Current chronic conditions of the lungs, liver and kidney, as well as cancer (chemotherapy and radiation) treatment in the past 12 months (allowances are made for non-melanoma skin cancer treatment, controlled asthma, and allergy inhalers)
  5. * Self-reported major neurological disorders or brain injuries (e.g., multiple sclerosis, cerebral palsy, major head injury)
  6. * Self-reported psychotic illnesses (mania, bipolar disorder, schizophrenia)
  7. * Current pregnancy or childbirth within the past 6 months
  8. * Suspected mild cognitive impairment or dementia
  9. * Self reported sleep apnea
  10. * Self-reported history of myocardial infarction, stroke, or revascularization procedures, as well as treatment for cardiac arrhythmias
  11. * Self-reported lack of comfort to undergo MRI testing
  12. * Presence of implants or objects that are unsafe for MRI (e.g., tattooed eyeliner), as well as any other contraindications that would prevent MRI testing
  13. * Self-reported lack of comfort to undergo the laboratory math task

Contacts and Locations

Study Contact

Peter J Gianaros, PhD
CONTACT
412-624-4500
bnl@pitt.edu
Sara Boyko, BS
CONTACT
412-648-9047
bnl@pitt.edu

Principal Investigator

Peter J Gianaros, PhD
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

  • Peter J Gianaros, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-10-17
Study Completion Date2029-06-30

Study Record Updates

Study Start Date2023-10-17
Study Completion Date2029-06-30

Terms related to this study

Additional Relevant MeSH Terms

  • Psychological Stress
  • Cardiovascular Diseases
  • Cerebrovascular Disorders