Cognitive and Vascular Functioning Following TBI

Eligibility Criteria

• 1. Active duty uniformed SM or Veteran who is currently eligible for treatment at WRNMMC (i.e., Defense Enrollment Eligibility Reporting System (DEERS)-eligible).
• 2. Ability to read, write, and speak English.
• 3. Ability to provide informed consent.
• 4. NICoE Intensive Outpatient Program (IOP) or NatHx Study comprehensive evaluation ≥3 years prior to current evaluation with valid neuropsychological test results.
• 5. Consent to allow access to prior research data collected through the NICoE TBI Neuroimaging Core Project or NatHx Study and consent to allow access to at least 1 prior blood specimen previously collected through these studies or the DoD Serum Biorepository.
• 1. History of at least one mild, moderate, severe, or penetrating TBI \> 3 years prior to enrollment. TBI will be diagnosed if any one of the following criteria immediately after the injury is met and attributed to the brain injury, rather than environmental/psychological/other injury factors (DoD-VA criteria246):
• 1. Loss of consciousness (LOC) or post-traumatic amnesia (PTA)
• 2. Alteration of consciousness (AOC)
• 3. Evidence of neurologic dysfunction
• 4. TBI-related abnormality on structural neuroimaging (either CT or MRI). Additional Healthy Control Criteria
• 1. History of military deployment.
• 2. Low history of blast exposure (i.e., \<10 blasts) Additional Blast Control Criteria
• 1. History of significant blast exposure (i.e., exposure to ≥ 10 blasts)
• 1. Disabling neurologic or psychological disorders such as autism, cerebral palsy, developmental disorder, stroke, brain tumor, multiple sclerosis, meningitis, encephalitis, brain abscess, vascular malformation, pre-injury epilepsy, schizophrenia, bipolar disorder, personality disorder
• 2. Diabetes mellitus requiring drug treatment
• 3. Hypertension requiring more than 1 antihypertensive drug to control BP
• 4. History of myocardial infarction or other systemic vasculopathies
• 5. Dementia diagnosis at initial NICoE/NatHx Study assessment