LATe Cerclage in High-risk Pregnancies (LATCH)

Description

The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.

Conditions

Premature Birth

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.

Cervical Cerclage for Short Cervix at 24-26 Weeks of Gestation: a Randomized Controlled Trial

LATe Cerclage in High-risk Pregnancies (LATCH)

Condition
Premature Birth
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Thomas Jefferson University, Philadelphia, Pennsylvania, United States, 19107

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-50 years old, pregnant, assigned female at birth
  • * Singleton pregnancy
  • * TVU CL ≤25mm between 24 0/7 - 26 6/7 weeks of gestation
  • * Initial multifetal gestation with subsequent multifetal pregnancy reduction, or selective fetal termination performed \>14 weeks, or cotwin pregnancy loss diagnosed \>14 weeks
  • * Cerclage in situ
  • * Preterm labor, defined as painful regular uterine contractions and change in cervical dilation
  • * PPROM
  • * Active vaginal bleeding
  • * Suspected intraamniotic infection
  • * Major fetal structural abnormality or chromosomal disorder
  • * Placenta previa or accreta
  • * Other contraindication to cerclage placement
  • * Participation in another clinical trial related to preterm birth prevention, cerclage, or progesterone

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Thomas Jefferson University,

Moti Gulersen, MD, MSc, PRINCIPAL_INVESTIGATOR, Thomas Jefferson University

Study Record Dates

2027-02