Ultra Crave: An Investigation of Ultra-Processed Food

Description

This study experimentally investigates whether a reduction in ultra-processed (UP) food intake (1) causes aversive withdrawal symptoms in humans, (2) increases the motivational salience of UP food cues and, if so, (3) whether these factors undermine the ability to adhere to a low-UP diet. The following aims and hypotheses are tested: Aim 1: To investigate whether aversive physical, cognitive, and affective withdrawal symptoms emerge in response to reduced UP food intake compared to a high-UP diet, and whether this predicts failure to adhere to a low-UP diet. H1a: Reducing UP food intake will result in aversive physical, cognitive, and affective withdrawal symptoms, as indicated by 1) ecological momentary assessment (EMA) reports of aversive withdrawal symptoms, and 2) heart rate reactivity and subjective distress to an in-lab stressor. H1b: Aversive symptoms of UP food withdrawal will predict greater UP food intake and higher blood glucose levels when trying to adhere to a low UP diet. Aim 2: To investigate whether increased motivational salience of UP food cues emerges in response to reduced UP food intake, and whether this predicts failure to maintain a low-UP diet. H2a: Reducing UP food intake will result in increased motivational salience of UP food cues, as indicated by 1) EMA reports of UP food craving, 2) heart rate reactivity and subjective craving in a simulated fast-food restaurant, 3) heightened reinforcement value for UP food relative to other reinforcers, and 4) greater reward-related neural response to UP food cues. H2b: Increased motivational salience of UP food cues will predict greater UP food intake and higher blood glucose levels when trying to adhere to a low UP diet.

Conditions

Food Addiction

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Study Overview

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Study Details

Study overview

This study experimentally investigates whether a reduction in ultra-processed (UP) food intake (1) causes aversive withdrawal symptoms in humans, (2) increases the motivational salience of UP food cues and, if so, (3) whether these factors undermine the ability to adhere to a low-UP diet. The following aims and hypotheses are tested: Aim 1: To investigate whether aversive physical, cognitive, and affective withdrawal symptoms emerge in response to reduced UP food intake compared to a high-UP diet, and whether this predicts failure to adhere to a low-UP diet. H1a: Reducing UP food intake will result in aversive physical, cognitive, and affective withdrawal symptoms, as indicated by 1) ecological momentary assessment (EMA) reports of aversive withdrawal symptoms, and 2) heart rate reactivity and subjective distress to an in-lab stressor. H1b: Aversive symptoms of UP food withdrawal will predict greater UP food intake and higher blood glucose levels when trying to adhere to a low UP diet. Aim 2: To investigate whether increased motivational salience of UP food cues emerges in response to reduced UP food intake, and whether this predicts failure to maintain a low-UP diet. H2a: Reducing UP food intake will result in increased motivational salience of UP food cues, as indicated by 1) EMA reports of UP food craving, 2) heart rate reactivity and subjective craving in a simulated fast-food restaurant, 3) heightened reinforcement value for UP food relative to other reinforcers, and 4) greater reward-related neural response to UP food cues. H2b: Increased motivational salience of UP food cues will predict greater UP food intake and higher blood glucose levels when trying to adhere to a low UP diet.

Ultra Crave: A Biopsychobehavioral Investigation of Withdrawal From Ultra-Processed Food in Humans

Ultra Crave: An Investigation of Ultra-Processed Food

Condition
Food Addiction
Intervention / Treatment

-

Contacts and Locations

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 22 to 60 years of age
  • * English-speaking
  • * Must own an Android or iPhone Smartphone
  • * Live within a 1-hour radius of the laboratory
  • * endorsement of \> 4 symptoms on the YFAS 2.0 completed during eligibility screener; at the time of consent, symptom count must remain above threshold for food addiction (this discrepany is based on a previously found tendency during pilot testing to overestimate food addiction symptoms at the time of screening)
  • * Willing and able to follow specific dietary instructions provided by the study team
  • * Willing and able to attend 3 in-person lab visits
  • * Willing to complete 4 phone interviews about foods eaten in the past 24 hours
  • * Willing to report daily intake of food
  • * Like the taste of chocolate milkshake (for fMRI scan eligibility only).
  • * participants with a self-reported BMI \< 18.5 and \> 40
  • * Current diagnosis of disorder that may impact study results or the ability to safely complete study tasks (hypothyroidism (uncontrolled by medication), diabetes, etc.)
  • * History of food allergies
  • * Unable to respond to brief questionnaires within 90-minutes during the day
  • * Work night shifts or irregular shifts
  • * Restrictive dietary requirements (e.g., vegan) or high levels of picky eating
  • * Medications (e.g., insulin, antipsychotic medications) that may impact study results or safe completion of study tasks
  • * Diagnosis of severe mental illness (e.g., schizophrenia, bipolar disorder)
  • * Diagnosis of a restrictive eating disorder (e.g., Anorexia Nervosa, Bulimia Nervosa, purging disorder) within the last 5 years
  • * Current diagnoses of disorders that can impact reward/metabolic functioning
  • * 20+ pound weight fluctuation in the last 3-months
  • * Prior weight loss surgery (e.g., bariatric surgery)
  • * Currently pregnant, breastfeeding, trying to get pregnant, or within 6-months of having given birth
  • * High levels or high-risk intake of alcohol or caffeine
  • * Use of tobacco or nicotine in the past month
  • * Use of THC cannabis within the past week
  • * Unwillingness to abstain from THC cannabis, tobacco or nicotine during the main portion of the study (\~22 days)
  • * fMRI contraindications (e.g., claustrophobia, metal implants).
  • * inability to complete a random report within 90 minutes

Ages Eligible for Study

22 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Michigan,

Study Record Dates

2028-08-05