Sevoflurane's Effect on Neurocognition Study

Description

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose sevoflurane. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Conditions

Anesthesia, Pain, Amnesia

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose sevoflurane. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Sevoflurane's Effect on Neurocognition Study

Sevoflurane's Effect on Neurocognition Study

Condition
Anesthesia
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults, age 18-59, who are native English speakers with at least a high school education
  • * have normal hearing and memory
  • * be of normal body-weight
  • * be generally healthy (free from significant chronic disease)
  • * have none of the specific exclusion criteria
  • * have a valid email address and valid phone number throughout the study
  • * anticipate ability to participate in all visits required for the phase of the study in which they are enrolled
  • * being pregnant or attempting to conceive
  • * having a body mass index (BMI) \> 35
  • * having significant memory impairment or hearing loss
  • * having sleep apnea
  • * having chronic pain or frequently taking pain medication (including tramadol)
  • * having any severe or poorly-controlled medical problem (hypertension, diabetes)
  • * having neurologic or psychiatric disease, including anxiety, and depression
  • * having significant cardiac valvular disease or cardiomyopathy
  • * having a history of abnormal heartbeats (cardiac conduction abnormality or arrhythmia)
  • * having a history of seizures or convulsions
  • * having a history of liver disease
  • * having a history of asthma or other significant pulmonary disease
  • * having a history of malignant hyperthermia, muscular dystrophy, central core disease, or hyperkalemia
  • * being claustrophobic
  • * have metal implants or non-removable metal piercings
  • * having a history of adverse reaction to anesthetics
  • * daily alcohol or heavy alcohol use; history of alcohol abuse
  • * current daily smoker
  • * regular or recent marijuana use (including prescribed/medical marijuana)
  • * illicit drug use
  • * regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids
  • * current use of selective serotonin reuptake inhibitors (SSRIs), noradrenaline reuptake inhibitors (SNRIs), or monoamine oxidase inhibitors (MAOIs) and some other specific drugs phenytoin, carbamazepine, and rifampin
  • * history of QT prolongation
  • * hypersensitivity or allergic reaction to ondansetron (Zofran)

Ages Eligible for Study

18 Years to 59 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Keith M Vogt,

Keith M Vogt, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2025-07-01