RECRUITING

Sevoflurane's Effect on Neurocognition Study

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Conditions

AnesthesiaPainAmnesiafunctional MRIsevofluraneelectric nerve stimulationsedationfunctional connectivity

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose sevoflurane. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Official Title

Sevoflurane's Effect on Neurocognition Study

Quick Facts

Study Start:2024-01-17
Study Completion:2025-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06044740

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 59 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults, age 18-59, who are native English speakers with at least a high school education
  2. * have normal hearing and memory
  3. * be of normal body-weight
  4. * be generally healthy (free from significant chronic disease)
  5. * have none of the specific exclusion criteria
  6. * have a valid email address and valid phone number throughout the study
  7. * anticipate ability to participate in all visits required for the phase of the study in which they are enrolled
  1. * being pregnant or attempting to conceive
  2. * having a body mass index (BMI) \> 35
  3. * having significant memory impairment or hearing loss
  4. * having sleep apnea
  5. * having chronic pain or frequently taking pain medication (including tramadol)
  6. * having any severe or poorly-controlled medical problem (hypertension, diabetes)
  7. * having neurologic or psychiatric disease, including anxiety, and depression
  8. * having significant cardiac valvular disease or cardiomyopathy
  9. * having a history of abnormal heartbeats (cardiac conduction abnormality or arrhythmia)
  10. * having a history of seizures or convulsions
  11. * having a history of liver disease
  12. * having a history of asthma or other significant pulmonary disease
  13. * having a history of malignant hyperthermia, muscular dystrophy, central core disease, or hyperkalemia
  14. * being claustrophobic
  15. * have metal implants or non-removable metal piercings
  16. * having a history of adverse reaction to anesthetics
  17. * daily alcohol or heavy alcohol use; history of alcohol abuse
  18. * current daily smoker
  19. * regular or recent marijuana use (including prescribed/medical marijuana)
  20. * illicit drug use
  21. * regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids
  22. * current use of selective serotonin reuptake inhibitors (SSRIs), noradrenaline reuptake inhibitors (SNRIs), or monoamine oxidase inhibitors (MAOIs) and some other specific drugs phenytoin, carbamazepine, and rifampin
  23. * history of QT prolongation
  24. * hypersensitivity or allergic reaction to ondansetron (Zofran)

Contacts and Locations

Study Contact

Keith M Vogt, MD, PhD
CONTACT
4126473147
kev18@pitt.edu

Principal Investigator

Keith M Vogt, MD, PhD
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: Keith M Vogt

  • Keith M Vogt, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-17
Study Completion Date2025-07-01

Study Record Updates

Study Start Date2024-01-17
Study Completion Date2025-07-01

Terms related to this study

Keywords Provided by Researchers

  • functional MRI
  • sevoflurane
  • electric nerve stimulation
  • sedation
  • functional connectivity

Additional Relevant MeSH Terms

  • Anesthesia
  • Pain
  • Amnesia