A Study of Contralateral Limb Block

Description

This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralateral side.

Conditions

Limb Pain, Phantom

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Study Overview

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Study Details

Study overview

This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralateral side.

Sciatic Block in Contralateral Limb for Treatment of Refractory Phantom and Residual Limb Pain; a Double-Blind Randomized Controlled Trial

A Study of Contralateral Limb Block

Condition
Limb Pain, Phantom
Intervention / Treatment

-

Contacts and Locations

Mankato

Mayo Clinic Health System - Mankato, Mankato, Minnesota, United States, 56001

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Lower extremity amputation performed more than 12 months before study enrollment
  • * PLP/RLP in affected amputated limb \> 4 on NRS26
  • * Pain duration of more than 6 months despite a trial of conservative therapies for at least 2 months, including oral medications, topical medicines, physical therapy, and physical modalities (i.e., heat, cold, transcutaneous electrical nerve stimulation, phonophoresis)
  • * Willingness to undergo image guided diagnostic nerve block
  • * Refusal / inability to participate or provide consent
  • * Contraindications to diagnostic nerve block
  • * Non-neurogenic source of PLP/RLP
  • * Current opioid use \> 50 morphine milligram equivalents per day
  • * Any interventional pain treatment in the residual limb within the last 30 days
  • * Severe uncontrolled medical condition (i.e., hypertensive crisis, decompensated hypothyroidism)
  • * Use of investigational pain drug within past 30 days or other concurrent clinical trial enrollment

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Cole Cheney, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2024-12