RECRUITING

NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP

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Conditions

Hypercapnic Respiratory FailureAVAPSBIPAPNoninvasive ventilation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to compare two different modes of noninvasive ventilation in hypercapnic respiratory failure. The investigators will compare AVAPS and BIPAP S/T and hypothesize that AVAPS will result in a decreased length of stay in the ICU or on telemetry. Currently, noninvasive ventilation is the standard of care for hypercapnic respiratory failure. However, the most effective mode for patients with hypercapnic respiratory failure is unclear.

Official Title

NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP

Quick Facts

Study Start:2023-10-07
Study Completion:2026-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06047405

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Provision of signed and dated informed consent form directly by the patient; consent can also be obtained via a legal patient representative/health care proxy/surrogate
  2. 2. Stated willingness to comply with all study procedures and availability for the duration of the study
  3. 3. Male or female, aged 18 or older
  4. 4. Diagnosed with hypercapnic respiratory failure on admission (ABG)
  5. 5. Admitted to Lenox Hill Hospital medical intensive care unit or telemetry unit
  6. 6. Requiring noninvasive ventilation as determined by the treating physician for the treatment of hypercarbic respiratory failure
  1. 1. Patients who require ventilation at predetermined tidal volumes
  2. 2. Patients who require rapid and frequent IPAP adjustments to maintain a consistent tidal volume
  3. 3. Age less than 18 years of age
  4. 4. Currently intubated
  5. 5. Chronic tracheostomy
  6. 6. Pregnancy
  7. 7. Hypotension
  8. 8. Epistaxis (nosebleed)
  9. 9. Untreated pertussis
  10. 10. Acute sinusitis or Otitis media
  11. 11. Patients at risk of aspirating gastric contents
  12. 12. Patients with lack of spontaneous respiratory drive
  13. 13. Patients with the inability to maintain a patent airway or adequately clear secretions
  14. 14. Prisoners or other institutionalized individuals

Contacts and Locations

Study Contact

Sara Velichkovikj
CONTACT
(212)-434-4087
svelichkovik@northwell.edu

Principal Investigator

Margarita Oks, MD
PRINCIPAL_INVESTIGATOR
Lenox Hill Hospital/Northwell Health

Study Locations (Sites)

Lenox Hill Hospital
New York, New York, 10075
United States

Collaborators and Investigators

Sponsor: Northwell Health

  • Margarita Oks, MD, PRINCIPAL_INVESTIGATOR, Lenox Hill Hospital/Northwell Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-10-07
Study Completion Date2026-09-01

Study Record Updates

Study Start Date2023-10-07
Study Completion Date2026-09-01

Terms related to this study

Keywords Provided by Researchers

  • AVAPS
  • BIPAP
  • Hypercapnic respiratory failure
  • Noninvasive ventilation

Additional Relevant MeSH Terms

  • Hypercapnic Respiratory Failure