NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP

Description

The goal of this study is to compare two different modes of noninvasive ventilation in hypercapnic respiratory failure. The investigators will compare AVAPS and BIPAP S/T and hypothesize that AVAPS will result in a decreased length of stay in the ICU or on telemetry. Currently, noninvasive ventilation is the standard of care for hypercapnic respiratory failure. However, the most effective mode for patients with hypercapnic respiratory failure is unclear.

Conditions

Hypercapnic Respiratory Failure

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Study Overview

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Study Details

Study overview

The goal of this study is to compare two different modes of noninvasive ventilation in hypercapnic respiratory failure. The investigators will compare AVAPS and BIPAP S/T and hypothesize that AVAPS will result in a decreased length of stay in the ICU or on telemetry. Currently, noninvasive ventilation is the standard of care for hypercapnic respiratory failure. However, the most effective mode for patients with hypercapnic respiratory failure is unclear.

NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP

NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP

Condition
Hypercapnic Respiratory Failure
Intervention / Treatment

-

Contacts and Locations

New York

Lenox Hill Hospital, New York, New York, United States, 10075

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Provision of signed and dated informed consent form directly by the patient; consent can also be obtained via a legal patient representative/health care proxy/surrogate
  • 2. Stated willingness to comply with all study procedures and availability for the duration of the study
  • 3. Male or female, aged 18 or older
  • 4. Diagnosed with hypercapnic respiratory failure on admission (ABG)
  • 5. Admitted to Lenox Hill Hospital medical intensive care unit or telemetry unit
  • 6. Requiring noninvasive ventilation as determined by the treating physician for the treatment of hypercarbic respiratory failure
  • 1. Patients who require ventilation at predetermined tidal volumes
  • 2. Patients who require rapid and frequent IPAP adjustments to maintain a consistent tidal volume
  • 3. Age less than 18 years of age
  • 4. Currently intubated
  • 5. Chronic tracheostomy
  • 6. Pregnancy
  • 7. Hypotension
  • 8. Epistaxis (nosebleed)
  • 9. Untreated pertussis
  • 10. Acute sinusitis or Otitis media
  • 11. Patients at risk of aspirating gastric contents
  • 12. Patients with lack of spontaneous respiratory drive
  • 13. Patients with the inability to maintain a patent airway or adequately clear secretions
  • 14. Prisoners or other institutionalized individuals

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Northwell Health,

Margarita Oks, MD, PRINCIPAL_INVESTIGATOR, Lenox Hill Hospital/Northwell Health

Study Record Dates

2026-09-01