RECRUITING

Vision Loss Impact on Navigation in Virtual Reality

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).

Official Title

The Impact of Vision Loss on Naturalistic Behavior and Navigation in Virtual Reality

Quick Facts

Study Start:2023-11-28
Study Completion:2026-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06047717

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Residents of the United States or Canada
  2. * Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and/or CT scans)
  3. * Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.
  4. * Willing, able, and competent to provide their own informed consent
  5. * Cognitively able, responsible to understand written and oral instructions in English
  6. * Emmetropic or else wear corrective contact lenses inside the virtual reality headset
  1. * Those who have never driven or earned a drivers' license
  2. * Past or present ocular disease interfering with visual acuity
  3. * Best corrected visual acuity (BCVA) worse than 20/40 in either eye
  4. * Sustained damage to the dorsal lateral geniculate nucleus
  5. * Presence of diffuse, whole-brain degenerative processes
  6. * Presence of brain damage deemed by study staff to potentially interfere with outcome measures
  7. * History of traumatic brain injury
  8. * Documented history of drug/alcohol abuse
  9. * Diagnosis of cognitive or seizure disorders
  10. * Diagnosis of one-sided attentional neglect

Contacts and Locations

Study Contact

Evan Burr
CONTACT
585-275-5234
Evan_Burr@URMC.Rochester.edu

Study Locations (Sites)

University of Rochester
Rochester, New York, 14642
United States

Collaborators and Investigators

Sponsor: University of Rochester

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-11-28
Study Completion Date2026-10

Study Record Updates

Study Start Date2023-11-28
Study Completion Date2026-10

Terms related to this study

Keywords Provided by Researchers

  • Occipital stroke
  • Vision loss after stroke
  • Vision recovery
  • Vision restoration
  • Partial vision loss
  • Homonymous quadrantanopsia
  • Homonymous quadrantanopia
  • stroke

Additional Relevant MeSH Terms

  • Stroke, Ischemic
  • Quadrantanopia
  • Hemianopsia, Homonymous
  • Hemianopia, Homonymous
  • Hemianopia
  • Hemianopsia
  • Occipital Lobe Infarct
  • Visual Field Defect, Peripheral
  • Vision Loss Partial
  • Quadrantanopsia
  • Stroke Hemorrhagic