Novel Amblyopia Treatment With Virtual Reality Games

Eligibility Criteria

• * Moderate to severe unilateral amblyopia (logMAR best corrected visual acuity 0.3 to 1.3) associated with anisometropia and/or strabismus of ≤5pd
• * Age normal VA in the nonamblyopic eye
• * Spectacle correction (if required) worn for at least 16 weeks, or until stability of VA is demonstrated (\<0.1 logMAR change by the same testing method measured on 2 exams at least 8 weeks apart)
• * Interocular difference of ≥ 3 lines
• * No amblyopia treatment in the past 2 weeks
• * An interpupillary distance of 52-72 mm (inclusive)
• * Myopia greater than -6.00 diopters (D) spherical equivalent in either eye.
• * Previous intraocular or refractive surgery.
• * Previous dichoptic treatment \> 2 weeks in duration
• * Ocular co-morbidity that may reduce visual acuity determined by an ocular examination performed within the past 7 months (Note: nystagmus per se does not exclude the participant if the above visual acuity criteria are met).
• * Diplopia more than once per week over the last week prior to enrollment by parental report.
• * Down syndrome or cerebral palsy.
• * Light-induced seizures
• * Known simulator sickness
• * Severe developmental delay that would interfere with treatment or evaluation (in the opinion of the investigator). Participants with mild speech delay or reading and/or learning disabilities are not excluded.