RECRUITING

Spatial-Motor Stroke-Rehab Study

Conditions

Spatial Neglect Stroke Post-stroke Prism Adaptation Therapy (PAT)Walking

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to understand how prism adaptation training with and without electrical stimulation changes visuospatial behavior, motor system neurophysiology, and walking dysfunction.

Official Title

Novel Spatial-Motor Approaches to Improve Spatial Neglect and Walking Deficits Post-Stroke

Quick Facts

Study Start:2023-04-11

Study Completion:2025-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06053320

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 90 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* 18-30 years * Able-Bodied (healthy without any physical disability or neurological disorder) * 45-90 years * Able-Bodied (healthy without any physical disability or neurological disorder) * \>3 months following stroke. * Presence of Aiming SN * Ability to walk \>10m with or without assistive devices. * Unilateral left-sided hemiparesis with gross arm strength of ≤ grade 4/5 on the Medical Research Council Scale * Ability to follow 3-stage commands and provide informed consent.	* History or evidence of orthopedic or physical disability * History or evidence of neurological pathology * Pregnancy (female) * Uncontrolled hypertension * Cardiac pacemaker or other implanted electronic system * Presence of skin conditions preventing electrical stimulation setup * Impaired sensation in the left upper limb. * Bruises or cuts at the stimulation electrode placement site * Concurrent enrollment in rehabilitation or another investigational study. * History or evidence of orthopedic or physical disability interfering with study procedures * History or evidence of neurological pathology or disorder * Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) that may interfere with study procedures * Contraindications to TMS such as metal implants, medications that can increase cortical excitability, unexplained dizziness in the past 6 months * History of multiple strokes or brainstem strokes * Cerebellar disorders * Impaired sensation in the left upper limb. * History of other neurological disorders * Uncontrolled hypertension * Cardiac pacemaker or other implanted electronic system * Pregnancy (female) * Presence of skin condition * Bruises at the electrode placement site * Concurrent enrollment in rehabilitation or another investigational study * Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) or other medical conditions that can interfere with study procedures * Contraindications to TMS such as metal implants in the brain, medications that will increase cortical excitability, etc.

Inclusion Criteria

Exclusion Criteria

* 18-30 years
* Able-Bodied (healthy without any physical disability or neurological disorder)
* 45-90 years
* Able-Bodied (healthy without any physical disability or neurological disorder)
* \>3 months following stroke.
* Presence of Aiming SN
* Ability to walk \>10m with or without assistive devices.
* Unilateral left-sided hemiparesis with gross arm strength of ≤ grade 4/5 on the Medical Research Council Scale
* Ability to follow 3-stage commands and provide informed consent.

* History or evidence of orthopedic or physical disability
* History or evidence of neurological pathology
* Pregnancy (female)
* Uncontrolled hypertension
* Cardiac pacemaker or other implanted electronic system
* Presence of skin conditions preventing electrical stimulation setup
* Impaired sensation in the left upper limb.
* Bruises or cuts at the stimulation electrode placement site
* Concurrent enrollment in rehabilitation or another investigational study.
* History or evidence of orthopedic or physical disability interfering with study procedures
* History or evidence of neurological pathology or disorder
* Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) that may interfere with study procedures
* Contraindications to TMS such as metal implants, medications that can increase cortical excitability, unexplained dizziness in the past 6 months
* History of multiple strokes or brainstem strokes
* Cerebellar disorders
* Impaired sensation in the left upper limb.
* History of other neurological disorders
* Uncontrolled hypertension
* Cardiac pacemaker or other implanted electronic system
* Pregnancy (female)
* Presence of skin condition
* Bruises at the electrode placement site
* Concurrent enrollment in rehabilitation or another investigational study
* Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) or other medical conditions that can interfere with study procedures
* Contraindications to TMS such as metal implants in the brain, medications that will increase cortical excitability, etc.

Contacts and Locations

Study Contact

Fisayo Aloba, PT, DPT

CONTACT

404-712-5803

olufisayo.aloba@emory.edu

Principal Investigator

Trisha Kesar, PT, PhD

PRINCIPAL_INVESTIGATOR

Emory University

Fisayo Aloba, PT, DPT

PRINCIPAL_INVESTIGATOR

Emory University

Study Locations (Sites)

Emory Rehabilitation Hospital

Atlanta, Georgia, 30322

United States

Emory University Hospital (EUH)

Atlanta, Georgia, 30322

United States

Executive Park

Atlanta, Georgia, 30329

United States

Collaborators and Investigators

Sponsor: Emory University

Trisha Kesar, PT, PhD, PRINCIPAL_INVESTIGATOR, Emory University
Fisayo Aloba, PT, DPT, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-11

Study Completion Date2025-12-31

Study Record Updates

Study Start Date2023-04-11

Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

Post-stroke
Prism Adaptation Therapy (PAT)
Walking

Additional Relevant MeSH Terms

Spatial Neglect
Stroke