A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM)

Eligibility Criteria

• * Confirmed prior diagnosis of smoldering myeloma (anytime prior). However, confirmation of SMM diagnosis must be documented in their last local oncologist clinic note within 6 months prior to study enrollment.
• * Age ≥18 years
• * Willingness to comply with all study-related procedures
• * Physically able to complete requirements for the study or has someone to assist with the requirements (such as meal preparation, stool shipment and survey completion)
• * Interested in learning to cook plant based recipes
• * Access to smart mobile phone or device with camera and ability to download Keenoa app
• * Be residing within the United States for the study duration.
• * English speaking or a family member or caregiver who speaks English and is able to assist with the surveys and phone based Keenoa app.
• * Taking any supplements other than vitamin D, iron, vitamin B12, potassium, magnesium, calcium or those needed for a medical indication must be reviewed by PI. If patient is on a supplement (including curcumin, probiotic, omega3) they must stop these for 2 weeks prior to enrollment on study.
• * Patients that already follow a whole foods plant based diet (ovo-lactovegetarian or processed junk food vegan diets are not excluded). This will be per research dietitian evaluation and discretion after nutrition screening.
• * Legume allergy
• * Severe allergies such as anaphylactic shock to peanuts and/or tree nuts, such as cashews
• * Concurrent participation in weight loss/dietary trials or defined programs (that require specified diets/supplements on the program)
• * Concurrent use of prescription weight loss (such as semaglutides and tirzepatides) and/or therapeutic myeloma drugs such as daratumumab, lenalidomide, etc.) within 12 weeks of consent
• * Mental impairment leading to inability to cooperate
• * Enrollment onto any other therapeutic investigational study
• * Concurrent pregnancy
• * Patients on full dose anticoagulation
• * ≥ Grade 2 electrolyte (sodium and potassium) abnormalities as defined by CTCAEv5.0 (need to be resolved before enrolling on study)
• * If in the opinion of the investigator there maybe any concerns regarding the ability of the patient to complete the study safely
• * Current self reported heavy alcohol use (defined as \>2 drinks per day or \>14 drinks per week)
• * Current self-reported illicit drug use (except inhaled marijuana, vaping or cigarette smoking. Oral marijuana/THC excluded or must stop \>2 weeks prior.)
• * Has a condition requiring antibiotics within 14 days of study intervention administration.
• * Plan for travel during the study that would preclude adherence to prescribed diets
• * History of active inflammatory bowel disease or major gastrointestinal surgery (not including appendectomy or cholecystectomy) within 3 months of enrollment or any history of total colectomy, or bariatric surgery (bariatric surgery which does not disrupt the gastrointestinal lumen, i.e. restrictive procedures such as banding, are permitted)