Biomarkers of Reaction To HIIT Exercise

Description

Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.

Conditions

Stroke, Stroke Rehabilitation, Lower Extremity Weakness, Spastic, Walking, Difficulty

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Study Overview

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Study Details

Study overview

Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.

What Makes a Responder, a Responder? Biomarkers to Help Identify Responders and Resistors to High-intensity Interval Training for Lower Extremity Chronic Stroke

Biomarkers of Reaction To HIIT Exercise

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Decatur

Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia, United States, 30033-4004

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident
  • * lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m/s during a 10m walk
  • * Veteran status
  • * MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia
  • * any neurodegenerative condition other than stroke that may lead to lower extremity impairment
  • * a visual or auditory impairment that may hinder study procedures
  • * any medical condition that would preclude participation in a physical exercise intervention program

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Lisa C Krishnamurthy, PhD, PRINCIPAL_INVESTIGATOR, Atlanta VA Medical and Rehab Center, Decatur, GA

Study Record Dates

2027-12-01