RECRUITING

Potassium, Hydration, Cardiovascular, and Kidney Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Compared with White Adults, Non-Hispanic Black Adults are at an elevated risk of developing cardiovascular disease (CVD) and end stage chronic-kidney disease (CKD), two of the leading causes of death in the United States. Inadequate hydration status is associated with risk factors for both CVD and CKD. Prior data show that Black individuals are less likely to be adequately hydrated when compared with their White counterparts. Further, socioeconomic factors have been shown to influence hydration practices. Inadequate hydration influences certain hormones that regulate blood volume and impact blood pressure, but increasing potassium intake may provide some positive effects on normalizing these hormones and blood pressure. Black adults, in particular, are more likely to consume less potassium, have inadequate hydration, and tend to have higher blood pressure. As such, there is a critical need for effective strategies to address racial disparities in hydration and resultant health consequences; as well as establish the role of socioeconomic factors contributing to hydration. Therefore, the investigators are seeking to test the investigators' central hypothesis that water with a potassium supplement will improve hydration and cardiovascular health in young White adults (n = 20, 10 females, 10 males), and to a greater extent in young Black Adults (n = 20, 10 females, 10 males. The investigators will assess measures of blood pressure, arterial stiffness, and biomarkers in the urine and blood samples prior to and following a 14-day hydration intervention of 1) bottled water and 2) bottled water with potassium supplementation (2000mg potassium/day).

Official Title

The Effects of Water and Potassium Supplementation on Cardiovascular and Kidney Function in Young Adults

Quick Facts

Study Start:2024-11-06
Study Completion:2027-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06062017

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 30 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Between the ages of 18-30 years
  2. * Resting blood pressure no higher than 150/90 mmHg
  3. * BMI below 35 kg/m2
  4. * Free of any metabolic disease (e.g., diabetes) kidney disease, pulmonary disorders (e.g., COPD), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular), no autoimmune diseases, and no history of cancer.
  1. * Have any precluding medical conditions (i.e. hemophilia) or medication (Pradaxa, Eliquis, etc.) that prevent participants from giving blood.
  2. * Are currently pregnant or trying to become pregnant.
  3. * take any of the following medications that are contraindicated with potassium supplementation:
  4. * Renin-angiotensin-aldosterone system (RAAS) blockers: Candesartan , Eprosartan, Irbesartan, Losartan, Olmesartan, Telmisartan
  5. * Non -steroidal anti-inflammatory medications: Aspirin, Ibuprofen, Naproxen
  6. * Non-selective beta-blockers: Pindolol, Penbutolol, Oxprenolol, Propranolol, Nadolol, Sotalol, Timolol, Tertatolol
  7. * Calcineurin inhibitors: Cyclosporine
  8. * Heparin (or other blood thinning medications)

Contacts and Locations

Study Contact

Nina L Stute, M.S.
CONTACT
9373071608
NLS0028@auburn.edu
Meral A Culver, M.S.
CONTACT
3017428813

Principal Investigator

Austin T Robinson, Ph.D.
STUDY_DIRECTOR
Indiana University
L. Bruce Gladden, Ph.D.
STUDY_DIRECTOR
Auburn University

Study Locations (Sites)

Kinesiology Building
Auburn, Alabama, 36849
United States

Collaborators and Investigators

Sponsor: Auburn University

  • Austin T Robinson, Ph.D., STUDY_DIRECTOR, Indiana University
  • L. Bruce Gladden, Ph.D., STUDY_DIRECTOR, Auburn University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-11-06
Study Completion Date2027-07

Study Record Updates

Study Start Date2024-11-06
Study Completion Date2027-07

Terms related to this study

Keywords Provided by Researchers

  • Racial disparities
  • Hydration
  • Blood pressure
  • Vascular function
  • Potassium

Additional Relevant MeSH Terms

  • Blood Pressure
  • Hydration
  • Vascular Disease Risk