Neonatal Pulse Oximetry Disparities Due to Skin Pigmentation

Description

The goal of this clinical trial is to determine if pulse oximeters show an SaO2-SpO2 discrepancy that correlates with skin pigmentation such that pulse oximetry will overestimate oxygenation in newborns with darker skin. The main questions it aims to answer is if SaO2-SpO2 discrepancy varies with the degree of skin pigmentation among neonates, if gestational age has an influence on SaO2-SpO2 discrepancy, and if packed red blood cell (PRBC) transfusion has an influence on SaO2-SpO2 discrepancy in newborns with various degrees of light and dark skin. Researchers will compare SaO2 and SpO2 values in neonates of various skin pigmentation.

Conditions

Skin Pigment, Pulse Oximetry

Study Overview

Study Details

Study overview

The goal of this clinical trial is to determine if pulse oximeters show an SaO2-SpO2 discrepancy that correlates with skin pigmentation such that pulse oximetry will overestimate oxygenation in newborns with darker skin. The main questions it aims to answer is if SaO2-SpO2 discrepancy varies with the degree of skin pigmentation among neonates, if gestational age has an influence on SaO2-SpO2 discrepancy, and if packed red blood cell (PRBC) transfusion has an influence on SaO2-SpO2 discrepancy in newborns with various degrees of light and dark skin. Researchers will compare SaO2 and SpO2 values in neonates of various skin pigmentation.

Neonatal Pulse Oximetry Disparities Due to Skin Pigmentation

Neonatal Pulse Oximetry Disparities Due to Skin Pigmentation

Condition
Skin Pigment
Intervention / Treatment

-

Contacts and Locations

Sacramento

UC Davis Health, Sacramento, California, United States, 95817

Jackson

University of Mississippi Medical Center, Jackson, Mississippi, United States, 39216

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Newborns postnatal age \< 10 days admitted to intensive care unit
  • * Presence of arterial catheter or undergoing arterial stick blood gas sampling
  • * Presence of abnormal hemoglobin (including methemoglobin \> 3%) - likely to only be known after enrolled and the blood gas is obtained
  • * Those in whom SpO2 cannot be measured in the same extremity as the arterial catheter.

Ages Eligible for Study

to 10 Days

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, Davis,

Study Record Dates

2025-01