Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease

Description

The purpose of this research is to determine whether or not low-intensity shockwave therapy (LiSWT) with Xiaflex treatment will result in greater improvements to the curvature of the penis.

Conditions

Peyronie Disease, Erectile Dysfunction

Study Overview

Study Details

Study overview

The purpose of this research is to determine whether or not low-intensity shockwave therapy (LiSWT) with Xiaflex treatment will result in greater improvements to the curvature of the penis.

Impact of Concurrent Low Intensity Shockwave Therapy on Clinical Outcomes With Collagenase Clostridium Histolyticum in Peyronie's Disease: A Randomized Controlled Trial

Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease

Condition
Peyronie Disease
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic Minnesota, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Prior intralesional injections or surgery for PD.
  • * Severe baseline penile pain.
  • * Moderate or severe baseline ED based on IIEF-EF domain.
  • * History of low intensity shockwave therapy for sexual dysfunction (ED or PD).
  • * Ventral (downward) or ventrolateral penile curvature.
  • * Moderate or severe (grade 2/3) plaque calcification as determined by PDDU.
  • * Inability to achieve satisfactory erection rigidity at time of baseline curvature assessment.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Tobias Kohler, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2025-12