RECRUITING

Propranolol in Primary Progressive Aphasia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure. This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.

Official Title

Trial of Propranolol in Older Adults With Primary Progressive Aphasia

Quick Facts

Study Start:2024-10
Study Completion:2026-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06066710

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 1. Age: 50 and older
  2. * 2. Primary Progressive Aphasia diagnosis
  3. * 3. Native English speaker
  1. * 1. Unable to provide consent
  2. * 2. Taking alpha 2 agonists (clonidine and guanfacine)
  3. * 3. Other major psychological or neurological diagnosis
  4. * 4. Major head trauma that contributed to their condition
  5. * 5. Allergic reaction to adhesives
  6. * 6. Uncorrected vision/hearing impairments
  7. * 7. Diabetes
  8. * 8. Reactive airway disease
  9. * 9. Untreated hypothyroidism
  10. * 10. Bradyarrhythmia
  11. * 11. Unexplained syncope
  12. * 12. Pregnancy (assessed verbally on the days of MR imaging)
  13. * 13. Drugs that interact with propranolol, such as alpha 2 agonists
  14. * 14. Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning. Subjects with any implanted device that cannot be verified as MRI compliant will be excluded.

Contacts and Locations

Study Contact

David Beversdorf, MD
CONTACT
573-882-6081
beversdorfd@health.missouri.edu
Joanne Cassani, RN
CONTACT
573-882-3677
cassanij@health.missouri.edu

Principal Investigator

David Beversdorf, MD
PRINCIPAL_INVESTIGATOR
University of Missouri-Columbia

Study Locations (Sites)

University of Missouri-Columbia
Columbia, Missouri, 65212
United States

Collaborators and Investigators

Sponsor: University of Missouri-Columbia

  • David Beversdorf, MD, PRINCIPAL_INVESTIGATOR, University of Missouri-Columbia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10
Study Completion Date2026-10

Study Record Updates

Study Start Date2024-10
Study Completion Date2026-10

Terms related to this study

Additional Relevant MeSH Terms

  • Aphasia, Primary Progressive