Evaluation of the Electronic Cigarette Withdrawal Syndrome

Description

The goal of this project is to rigorously evaluate the nature of e-cigarette withdrawal in exclusive e-cigarette users during a monitored abstinence period and the role of nicotine in the expression of this withdrawal syndrome.

Conditions

E-cigarette Use, Withdrawal

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Study Overview

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Study Details

Study overview

The goal of this project is to rigorously evaluate the nature of e-cigarette withdrawal in exclusive e-cigarette users during a monitored abstinence period and the role of nicotine in the expression of this withdrawal syndrome.

Evaluation of the Electronic Cigarette Withdrawal Syndrome: Mechanistic Targets for Intervention

Evaluation of the Electronic Cigarette Withdrawal Syndrome

Condition
E-cigarette Use
Intervention / Treatment

-

Contacts and Locations

Baltimore

Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States, 21224

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. 21-55 years old
  • 2. good general health as reviewed by study medical team
  • 3. vital signs in normal range as reviewed by study medical team
  • 4. negative urine test for illicit drug use (excluding THC) and negative breath alcohol test
  • 5. daily use of a nicotine-containing e-cigarette for at least 6 months
  • 6. no regular use of other tobacco products (e.g., smokeless products) for at least 6 months
  • 7. urine cotinine \>100ng/mL (i.e., recommended cutoff for confirming current nicotine use)
  • 8. exhaled breath carbon monoxide (CO) \<6ppm
  • 9. Penn State E-cigarette Dependence (PSED) score \>=4, indicating mild dependence or greater
  • 10. have an interest in reducing e-cigarette use
  • 1. psychoactive drug use (aside from cannabis, nicotine, alcohol, caffeine) in past month
  • 2. current use of over-the-counter (OTC) or prescription medications that may impact safety
  • 3. use cannabis \>2 times per week
  • 4. history of or current significant medical condition that would impact participation or safety according to the study investigators and medical staff
  • 5. current psychiatric condition or substance use disorder (aside from tobacco use disorder) that would impact participation or safety according to the study investigators and medical staff
  • 6. enrollment in another trial
  • 7. positive pregnancy test
  • 8. currently using a nicotine/tobacco cessation product
  • 9. seizure disorder or traumatic brain injury (TBI)

Ages Eligible for Study

21 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

Justin Strickland, Ph.D., PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2028-08-31