Reducing Frailty for Older Cancer Survivors Using Supplements II

Eligibility Criteria

• 1. Be age 65 or over.
• 2. Be diagnosed with stage I-III Cancer
• 3. Have completed curative intent treatment ≤10 years prior to screening (Patients on endocrine therapies are allowed to enroll)
• 4. Have a Fried's Frailty Score (FFS) of ≥ 2
• 5. Able to provide informed consent, or have consent given by patient-designated health care proxy per institutional policies and University of Rochester Cancer Control URCC guidelines.
• 1. Have chemotherapy planned for the duration of the study.
• 2. Have abnormal liver function tests (Alanine transaminase (ALT), Aspartate transaminase (AST), and bilirubin ≥ 3 times institutional upper limit of normal) per most recent available lab test (within 3 months of screening).
• 3. Have uncontrolled or unmanaged liver disease.
• 4. Consume more than 6 cups of green tea per day.
• 5. Have known allergies to caffeine.
• 6. Be diagnosed with a major psychiatric illness requiring hospitalization within the last year.
• 7. Be diagnosed with dementia.
• 8. Cannot provide informed consent due to lack of decision-making capacity (as determined by the patient's oncologist) and has no patient-designated health care proxy per institutional policies and University of Rochester Cancer Control University of Rochester Cancer Control (URCC) guidelines.