Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period

Description

Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely understood. Habitual short sleepers are constantly eating, the proposed studies will evaluate if this behavior contributes to heightened cardiovascular and metabolic risk. The study will evaluate if restricted eating duration (8 hours/day) could improve cardiovascular and metabolic health in habitual short sleepers.

Conditions

Sleep Deprivation

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Study Overview

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Study Details

Study overview

Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely understood. Habitual short sleepers are constantly eating, the proposed studies will evaluate if this behavior contributes to heightened cardiovascular and metabolic risk. The study will evaluate if restricted eating duration (8 hours/day) could improve cardiovascular and metabolic health in habitual short sleepers.

Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period

Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period

Condition
Sleep Deprivation
Intervention / Treatment

-

Contacts and Locations

Baton Rouge

Recruiting core Pennington, Baton Rouge, Louisiana, United States, 70808

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age: 18-45 years
  • * BMI: 25-35 kg/m2
  • * Habitual sleep duration: ≤6.5 h/night
  • * Habitual eating period: \>14h/day
  • * Absence of chronic health conditions including hypertension (defined as systolic clinical BP of \>140 or diastolic BP of \>90 mmHg or use of BP lowering drugs), dyslipidemia (defined as LDL \>190mg/dL or Triglycerides \>400 mg/dL or use of lipid lowering medications), diabetes (defined as fasting glucose \>126 mg/dL and /or HbA1C \>6.5%, or use of glucose lowering medication), and cardiovascular disease. However, individuals with prehypertension, and/or prediabetes will be allowed to participate.
  • * Individuals with seasonal allergies will also be included.
  • * Women of child-bearing age will be allowed to participate if they agree to use acceptable birth control during the study period.
  • * Must be able to provide written informed consent.
  • * Ability to follow the prescribed eating duration and maintain habitual diet, sleep and physical activity.
  • * Use of certain mediations will be allowed including birth control, second generation antihistamines, antacids, acne-related ointments etc.
  • * Irregular sleep habits / night shift / rotating shift work in past 1 month.
  • * Frequent travel related jet lag.
  • * Pregnant/ breast-feeding/ history of irregular menstrual cycles.
  • * Sleep disorders such as insomnia (defined as Insomnia Severity Index score ≥15), and sleep apnea (overnight oximetry defined oxygen desaturation index of \>10 events/h of sleep).
  • * Presence of excessive daytime sleepiness (defined as Epworth Sleepiness Scale score \>10).
  • * Recent changes in body weight (≥5%) within 3 months.
  • * Uncontrolled depression and /or anxiety, history of psychosis or bipolar disorder.
  • * Uncontrolled depression and/or depression is defined as PHQ-9 score of ≥15 or a positive response for suicidal thoughts (Q9 of the PHQ-9 - any response other than not at all).
  • * Any medication or condition that, in the opinion of the medical investigator, could interfere with the study outcomes or put the subject at risk by participating in the study.
  • * Blood or plasma donation during the past 2 months.

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Pennington Biomedical Research Center,

Prachi Singh, PhD, PRINCIPAL_INVESTIGATOR, Pennington Biomedical Research Institute

Study Record Dates

2028-06-30