Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain

Description

The goal of this pilot study is to describe and compare Ultrasound-Guided Erector Spinae Plane (ESP) Blocks using Exparel® (bupivacaine liposome injectable suspension) to Marcaine® (bupivacaine hydrochloride) for pain management and outcomes after cardiac surgeries.

Conditions

Pain, Postoperative, Opioid Use, Perioperative Complication, Heart Diseases

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Study Overview

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Study Details

Study overview

The goal of this pilot study is to describe and compare Ultrasound-Guided Erector Spinae Plane (ESP) Blocks using Exparel® (bupivacaine liposome injectable suspension) to Marcaine® (bupivacaine hydrochloride) for pain management and outcomes after cardiac surgeries.

Randomized Control Trial to Assess the Efficacy of Preoperative Erector Spinae Blocks on Cardiac Surgery Postoperative Outcomes

Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain

Condition
Pain, Postoperative
Intervention / Treatment

-

Contacts and Locations

New Brunswick

Rutgers RWJMS, New Brunswick, New Jersey, United States, 08903

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults (18 years-no upper age limit)
  • * Scheduled for mini thoracotomy (i.e. valve repair) or open sternotomy (i.e. bypass graft) at single academic medical center (in and out-patients).
  • * Are currently on pain medication or pain regimen for chronic pain condition
  • * Convert to sternotomy (for thoracotomies)
  • * Require, upon intraoperative discovery and surgeon's decision, the need for an unplanned secondary procedure other than the originally scheduled index operation
  • * Undergo emergent surgery
  • * Are non-English speaking (The majority of the PI's patient population speak English. As a pilot study the investigators cannot afford to enroll non-English speaking subjects due to time, personnel, and financial constraints.)
  • * Mechanical circulatory support (MCS)
  • * Vasoactive medications
  • * Intubated
  • * Active infection
  • * Patients otherwise deemed ineligible for ESP block by the investigators due to safety concerns.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Rutgers, The State University of New Jersey,

Leonard Y Lee, MD, PRINCIPAL_INVESTIGATOR, Rutgers Robert Wood Johnson Medical School, Dept of Surgery

Study Record Dates

2025-04-05