Effect of Anti-inflammatory Diet in Osteoarthritis

Description

In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.

Conditions

Osteoarthritis, Knee

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Study Overview

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Study Details

Study overview

In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.

An Evaluator-blinded Randomized Controlled Trial Study of the Effect of Anti-inflammatory Diet in Subjects With Osteoarthritis

Effect of Anti-inflammatory Diet in Osteoarthritis

Condition
Osteoarthritis, Knee
Intervention / Treatment

-

Contacts and Locations

San Diego

University of California, San Diego, California, United States, 92122

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Unilateral radiographic symptomatic KOA
  • * No changes in therapy during the previous 3 months
  • * Interested in dietary intervention and able to provide consent and attend follow-up visits
  • * Previous knee surgery
  • * Severe radiographic disease (KL grade 4)
  • * Rheumatoid Arthritis
  • * Any Abnormal blood values in the comprehensive metabolic panel test at screen (Abnormality will be defined based on standard reference ranges)
  • * Use of corticosteroids and/or intra-articular injections during the preceding 3 months
  • * Use of fish oils and glucosamine
  • * Participation in a weight loss program in the preceding 6 months
  • * Recent changes in physical activity levels
  • * Regular smoking
  • * Patients with food allergies
  • * Patient with other medical conditions that will impair the ability to participate in a nutritional study
  • * Plan to change systemic therapy
  • * Patients unwilling to change dietary habits

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Study Record Dates

2026-01-01