Study of GS-9911 With or Without Antibody Treatment for Adults With Solid Tumors

Eligibility Criteria

• * Parts A, C, and D:
• * Participants with histologically or cytologically confirmed advanced solid tumors who have received, been intolerant to, or are ineligible for all treatments known to confer clinical benefit
• * Part B:
• * Participants whose cancer previously derived clinical benefit from immune checkpoint inhibitors, or who have advanced solid tumor types for which immune checkpoint inhibitors are considered the standard of care and who have received, been intolerant to, or are ineligible for all treatments known to confer clinical benefit
• * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• * Evaluable (Part A) or measurable (Parts B, C, and D) disease as per Response Criteria Evaluation in Solid Tumors (RECIST) v1.1 criteria
• * Adequate organ functions
• * Tissue requirement:
• * Parts A-D: must be willing to provide baseline tumor tissue prior to enrollment
• * Part A backfill cohorts: a biopsy should be obtained prior to treatment and on treatment, if safely feasible
• * Participants of childbearing potential who engage in heterosexual intercourse must agree to use protocol-specified methods of contraception
• * Positive serum pregnancy test or lactating female
• * History of intolerance, hypersensitivity, or treatment discontinuation due to life- threatening immune-related adverse events on prior immunotherapy
• * Receipt of the therapies listed below within the specified timeframe prior to planned Cycle 1 Day 1 including: major surgery (\< 4 weeks), immunotherapy or biologic therapy (\< 28 days), chemotherapy (\< 21 days), targeted small molecule therapy (\<14 days or 5 half-lives, whichever is sooner), hormonal or other adjunctive therapy (\< 14 days), radiation therapy (\< 21 days), live vaccine (\< 28 days)
• * Any prior allogeneic tissue/solid organ transplantation, including allogeneic stem cell transplantation
• * Diagnosis of immunodeficiency, or requires systemic corticosteroids (\> 10 mg of prednisone daily, or equivalent)
• * History of autoimmune disease or active autoimmune disease that has required systemic treatment within 2 years prior to the start of study drug
• * History of pneumonitis requiring treatment with corticosteroids, interstitial lung disease, drug-induced pneumonitis, or severe radiation pneumonitis (excluding localized radiation pneumonitis)
• * Active second malignancy. Note: individuals with a history of malignancy that have been completed treated, with no evidence of active cancer for 2 years prior to enrollment, or individuals with surgically cured tumors with low risk of recurrence are allowed to enroll.
• * Known active central nervous system (CNS) metastases and/or carcinomatous meningitis
• * Symptomatic cardiovascular disease
• * Active serious infection requiring ongoing treatment
• * Active infection with hepatitis B virus (HBV), hepatitis C virus (HCV), or HIV.
• * Symptomatic ascites or pleural effusion