RECRUITING

Test-retest Evaluation of [18F]F-AraG PET

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This pilot study aims to evaluate the test-retest variability of \[18F\]F-AraG-PET imaging in patients with advanced NSCLC tumors. The main objectives of the study are to quantify the uptake of \[18F\]F-AraG in tumors and lymphoid tissue in two consecutive scans spaced not longer than 7 days apart from each other to estimate the magnitude of physiologic and measurement variability. To explore these objectives, eligible subjects will undergo two \[18F\]F-AraG PET/CT scans within 7 days of each other prior to receiving treatment. This study is a single-site, open-label, non-randomized, single-arm pilot trial. Patients and care providers will not be blinded to any part of the study.

Official Title

Test-retest Evaluation of [18F]F-AraG PET in Non-small Cell Lung Cancer (NSCLC) Patients

Quick Facts

Study Start:2023-10-31
Study Completion:2025-10-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06084806

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Patients (\>18 years old) with a histologically confirmed NSCLC and a candidate to receive immunotherapy as monotherapy or as combination therapy for advanced/metastatic disease.
  2. 2. Measurable disease.
  3. 3. ECOG performance status of 0, 1 or 2.
  1. 1. Serious comorbidities that in the opinion of the investigator/sponsor could compromise protocol objectives.
  2. 2. Pregnant women or nursing mothers.
  3. 3. Patients with severe claustrophobia.

Contacts and Locations

Study Contact

Amy Mundisev
CONTACT
319-356-1445
amy-mundisev@uiowa.edu

Principal Investigator

Muhammad Furqan, M.D.
PRINCIPAL_INVESTIGATOR
Holden Comprehensive Cancer Center

Study Locations (Sites)

University of Iowa Hospitals and Clinics
Iowa City, Iowa, 52246
United States

Collaborators and Investigators

Sponsor: CellSight Technologies, Inc.

  • Muhammad Furqan, M.D., PRINCIPAL_INVESTIGATOR, Holden Comprehensive Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-10-31
Study Completion Date2025-10-31

Study Record Updates

Study Start Date2023-10-31
Study Completion Date2025-10-31

Terms related to this study

Additional Relevant MeSH Terms

  • Non-small Cell Lung Cancer