Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

Description

There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.

Conditions

Suicide, Suicidal Ideation, Depression

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Study Overview

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Study Details

Study overview

There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.

Feasibility and Safety of Single Dose Ketamine for Acutely Suicidal Patients in the Emergency Department

Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

Condition
Suicide
Intervention / Treatment

-

Contacts and Locations

Kansas City

University of Kansas Strawberry Hill Campus, Kansas City, Kansas, United States, 66101

Kansas City

University of Kansas Medical Center Emergency Department, Kansas City, Kansas, United States, 66160

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category)
  • * Require inpatient stabilization for SI or actions based on clinical observation and interview
  • * Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus
  • * Have a Glasgow Coma Score (GCS) of 15
  • * Age 18-65
  • * Current or past history of psychosis
  • * Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater
  • * History of ketamine use disorder
  • * History of liver transplant
  • * Pregnancy or breastfeeding
  • * Imprisonment or inability to consent
  • * Positive urine drug screen or serum alcohol level
  • * Hypertension (SBP \> 160 or DBP \> 100 before administration of ketamine)
  • * Hypotension (SBP \< 90)
  • * Presence of acute medical condition requiring admission to medical service
  • * Allergy, intolerance, or previous adverse reaction to ketamine
  • * Patient has 8+ lifetime ketamine exposures
  • * The treating physician determines that the patient is not a good candidate for the study (e.g. medical condition/procedure, medication that would contradindicate ketamine treatment)

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Lindsay Maguire, MD,

Study Record Dates

2025-04