5-Day Preoperative Radiation for Soft Tissue Sarcoma

Description

The purpose of this study is to examine the safety and efficacy of an abbreviated course of preoperative radiation, given over five days, for patients with soft tissue sarcoma of the extremity, trunk or retroperitoneum. This is in contrast to standard preoperative radiation, which is given over 25 days.

Conditions

Soft Tissue Sarcoma

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Study Overview

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Study Details

Study overview

The purpose of this study is to examine the safety and efficacy of an abbreviated course of preoperative radiation, given over five days, for patients with soft tissue sarcoma of the extremity, trunk or retroperitoneum. This is in contrast to standard preoperative radiation, which is given over 25 days.

Phase 2 5-Day Preoperative Radiation for Soft Tissue Sarcoma

5-Day Preoperative Radiation for Soft Tissue Sarcoma

Condition
Soft Tissue Sarcoma
Intervention / Treatment

-

Contacts and Locations

Palo Alto

Stanford University, Palo Alto, California, United States, 94305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Histologically confirmed soft tissue sarcoma of the extremity, trunk or retroperitoneum.
  • 2. Has been offered preoperative radiation and surgery as part of standard-of-care treatment
  • 3. Age ≥ 18
  • 4. KPS ≥ 70 or ECOG 0 to 2
  • 5. Life expectancy ≥ 6 months
  • 6. If a woman is of childbearing potential, a negative serum or urine pregnancy test must be documented.
  • 7. Ability to understand and the willingness to personally sign the written IRB approved informed consent document.
  • 1. History of prior radiation to the area to be treated.
  • 2. Active use of other anti-cancer investigational agents.
  • 3. Planned use of concurrent chemotherapy, targeted therapy, or immunotherapy with radiation therapy (defined as the time interval starting 1 week before the first and last fraction of radiation therapy and surgery).
  • 4. Pregnancy.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Anusha Kalbasi, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2026-01