A Study of Apremilast in Pediatric Participants in Children With Mild to Moderate Plaque Psoriasis

Eligibility Criteria

• * Participants must have a weight of ≥ 20 kg.
• * Participant must have an age and sex specific BMI value no lower in range than the fifth percentile on the growth chart for children and adolescents.
• * Participant is able to swallow the study medication tablet.
• * Diagnosis of chronic plaque psoriasis for at least 6 months prior to screening.
• * Has mild to moderate plaque psoriasis at screening and Study Visit 1 as defined by:
• * Psoriasis Area Severity Index score 2-15,
• * Body surface area 2-15%, and
• * Static Physician Global Assessment score of 2-3 (mild to moderate)
• * Disease inadequately controlled by or inappropriate for topical therapy for psoriasis.
• * Guttate, erythrodermic, or pustular psoriasis at screening and Study Day 1.
• * Psoriasis flare or rebound within 4 weeks prior to screening.
• * Active tuberculosis (TB) or a history of incompletely treated TB per local guidelines.
• * History of recurrent significant infections.
• * Active infection or infection treated with antibiotic treatment within 14 days of Study Day 1.
• * Any history of or active malignancy or myeloproliferative or lymphoproliferative disease.
• * Current use of the following therapies that may have a possible effect on psoriasis:
• * Conventional systemic therapy for psoriasis within 28 days prior to Study Day 1 (including but not limited to cyclosporine, corticosteroids, methotrexate, oral retinoids, mycophenolate, thioguanine, hydroxyurea, sirolimus, sulfasalazine, azathioprine, and fumaric acid esters).
• * Phototherapy treatment (ie, ultraviolet B \[UVB\], PUVA) within 28 days prior to Study Day 1.
• * Biologic therapy:
• * Etanercept (or biosimilar) treatment 28 days prior to Study Day 1
• * Adalimumab (or biosimilar) treatment 10 weeks prior to Study Day 1
• * Other TNF or IL-17 blockers (such as infliximab, certolizumab pegol, secukinumab, ixekizumab, brodalumab, or their biosimilars) within 12 weeks prior to Study Day 1
• * Anti-IL-12 or anti-IL-23 treatment (such as ustekinumab, guselkumab, or tildrakizumab) within 24 weeks prior to Study Day 1.
• * Use of tanning booths or other ultraviolet light sources.
• * Answer "Yes" to any question on the Columbia-Suicide Severity Rating Scale during screening or at Study Day 1.
• * Female participant of childbearing potential with a positive pregnancy test assessed at screening and/or Study Day 1 by a serum and/or urine pregnancy test.