Speech-in-noise Perception in Autism and Fragile X

Description

The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise? Participants will complete the following: * hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.

Conditions

Autism Spectrum Disorder, Fragile X Syndrome

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Study Overview

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Study Details

Study overview

The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise? Participants will complete the following: * hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.

Cortical Mechanisms of Speech in Noise Perception in Autism and Fragile X Syndrome

Speech-in-noise Perception in Autism and Fragile X

Condition
Autism Spectrum Disorder
Intervention / Treatment

-

Contacts and Locations

Cincinnati

Cincinnati Children'S Hospital, Cincinnati, Ohio, United States, 45229-3026

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. normal audiograms (PTA ≤ 20 dB HL)
  • 2. corrected 20/20 vision (Snellen chart)
  • 3. no history of premature birth (prior to 36 weeks gestation)
  • 4. no medications known to affect EEG signal
  • 5. English as the first language
  • 1. Documented PCR/Southern Blot genetic testing confirming full mutation FXS
  • 2. Diagnosis of Autism Spectrum Disorder, per Autism group.
  • 1. no siblings or parents with an Autism Spectrum Disorder or Fragile X Syndrome
  • 2. no current neurological or psychiatric diagnoses
  • 3. IQ over 75
  • * Hearing loss or uncorrected vision loss
  • * history of premature birth (prior to 36 weeks gestation)

Ages Eligible for Study

15 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Children's Hospital Medical Center, Cincinnati,

Elizabeth Smith, PhD, PRINCIPAL_INVESTIGATOR, Children's Hospital Medical Center, Cincinnati

Study Record Dates

2025-04-30