Behavioral and Neural Correlates of Post-Stroke Fatigue

Description

The goal of this phase I/II clinical trial is to determine the behavioral and neural effects of 5-daily transcranial direct current stimulation on post-stroke fatigue. The three aims are: Aim 1: Investigate the behavioral effect of 5 daily sessions of anodal tDCS over the ipsilesional M1 on PSF. Aim 2: Investigate the neurophysiological effect of 5 daily sessions of anodal tDCS over the ipsilesional M1. Aim 3: Determine the relationship between changes in M1 excitability, brain connectivity and changes in PSF. Participants will receive either a real or sham stimulation for 5 consecutive days and fatigue will be assessed before, immediately after and 1-month after the intervention. Fatigue will be assessed using clinical, behavioral, and neurophysiological outcomes.

Conditions

Stroke, Fatigue

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Study Overview

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Study Details

Study overview

The goal of this phase I/II clinical trial is to determine the behavioral and neural effects of 5-daily transcranial direct current stimulation on post-stroke fatigue. The three aims are: Aim 1: Investigate the behavioral effect of 5 daily sessions of anodal tDCS over the ipsilesional M1 on PSF. Aim 2: Investigate the neurophysiological effect of 5 daily sessions of anodal tDCS over the ipsilesional M1. Aim 3: Determine the relationship between changes in M1 excitability, brain connectivity and changes in PSF. Participants will receive either a real or sham stimulation for 5 consecutive days and fatigue will be assessed before, immediately after and 1-month after the intervention. Fatigue will be assessed using clinical, behavioral, and neurophysiological outcomes.

Behavioral and Neural Correlates of Post-Stroke Fatigue

Behavioral and Neural Correlates of Post-Stroke Fatigue

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Dallas

Texas Woman's University, Dallas, Texas, United States, 75235

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. be at least 18 years old;
  • 2. have a history of unilateral stroke ≥ 3 months prior to enrollment to ensure stability;
  • 3. have an average score ≥ 4 on FSS;
  • 4. have some movement capability in the more affected arm (upper extremity Fugl-Meyer(FMUE) ≥ 28) to ensure they can perform the reaching task;
  • 5. be able to follow three-step commands.
  • 1. acute medical problems;
  • 2. the presence of any contraindication to tDCS, MRI or TMS;
  • 3. the presence of significant depression (score \> 10 on the Patient Health Questionnaire-9);
  • 4. significant pain in the upper extremities that interferes with movements; or
  • 5. use of medication which may affect the level of fatigue.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Texas Woman's University,

Hui-Ting Goh, PRINCIPAL_INVESTIGATOR, Physical Therapy

Study Record Dates

2026-08-31