Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

Description

The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.

Conditions

Salt-Sensitivity of Blood Pressure

Talk to us

Study Overview

On this page

Study Details

Study overview

The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.

Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

Condition
Salt-Sensitivity of Blood Pressure
Intervention / Treatment

-

Contacts and Locations

Newark

University of Delaware, Newark, Delaware, United States, 19713

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age: \> 40 years or \< 60 years
  • * Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg
  • * BMI: \> 18.5 kg/m2 or \< 30 kg/m2
  • * Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L
  • * No history of cardiovascular, renal, metabolic, or neurological disease
  • * Age: \< 40 years or \> 60 years
  • * Blood pressure: \< 100/60 mmHg or \> 140/90 mmHg
  • * BMI: \< 18.5 kg/m2 or \> 30 kg/m2
  • * Serum potassium: \< 3.5 mmol/L or \> 5.5 mmol/L
  • * Abnormal ECG
  • * History of - cardiovascular, cancer, metabolic, respiratory, renal disease
  • * Hormone replacement therapy
  • * Current tobacco or nicotine use
  • * Pregnant or nursing mothers
  • * Major brain injury (concussions do not count)
  • * Clinically diagnosed psychiatric or neurological disorder
  • * Clinically diagnosed anxiety or depression
  • * Psychiatric, neurological, anxiety or depression medications
  • * Hypertension medications
  • * Sulfonamide drug allergy
  • * Contra-indications to MRI (implants, metal, etc)
  • * Claustrophobia

Ages Eligible for Study

40 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Delaware,

Study Record Dates

2028-07