RECRUITING

Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.

Official Title

Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

Quick Facts

Study Start:2024-03-05

Study Completion:2028-07

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06094816

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 60 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Age: \> 40 years or \< 60 years * Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg * BMI: \> 18.5 kg/m2 or \< 30 kg/m2 * Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L * No history of cardiovascular, renal, metabolic, or neurological disease	* Age: \< 40 years or \> 60 years * Blood pressure: \< 100/60 mmHg or \> 140/90 mmHg * BMI: \< 18.5 kg/m2 or \> 30 kg/m2 * Serum potassium: \< 3.5 mmol/L or \> 5.5 mmol/L * Abnormal ECG * History of - cardiovascular, cancer, metabolic, respiratory, renal disease * Hormone replacement therapy * Current tobacco or nicotine use * Pregnant or nursing mothers * Major brain injury (concussions do not count) * Clinically diagnosed psychiatric or neurological disorder * Clinically diagnosed anxiety or depression * Psychiatric, neurological, anxiety or depression medications * Hypertension medications * Sulfonamide drug allergy * Contra-indications to MRI (implants, metal, etc) * Claustrophobia

Inclusion Criteria

Exclusion Criteria

* Age: \> 40 years or \< 60 years
* Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg
* BMI: \> 18.5 kg/m2 or \< 30 kg/m2
* Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L
* No history of cardiovascular, renal, metabolic, or neurological disease

* Age: \< 40 years or \> 60 years
* Blood pressure: \< 100/60 mmHg or \> 140/90 mmHg
* BMI: \< 18.5 kg/m2 or \> 30 kg/m2
* Serum potassium: \< 3.5 mmol/L or \> 5.5 mmol/L
* Abnormal ECG
* History of - cardiovascular, cancer, metabolic, respiratory, renal disease
* Hormone replacement therapy
* Current tobacco or nicotine use
* Pregnant or nursing mothers
* Major brain injury (concussions do not count)
* Clinically diagnosed psychiatric or neurological disorder
* Clinically diagnosed anxiety or depression
* Psychiatric, neurological, anxiety or depression medications
* Hypertension medications
* Sulfonamide drug allergy
* Contra-indications to MRI (implants, metal, etc)
* Claustrophobia

Contacts and Locations

Study Contact

Megan Wenner, PhD

CONTACT

3028317343

mwenner@udel.edu

Virginia Nuckols, PhD

CONTACT

gnuckols@udel.edu

Study Locations (Sites)

University of Delaware

Newark, Delaware, 19713

United States

Collaborators and Investigators

Sponsor: University of Delaware

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-05

Study Completion Date2028-07

Study Record Updates

Study Start Date2024-03-05

Study Completion Date2028-07

Terms related to this study

Additional Relevant MeSH Terms

Salt-Sensitivity of Blood Pressure