Short Versus Long Duration of Therapy for Streptococcus Pneumoniae Bloodstream Infections

Description

Streptococcus pneumoniae is a gram-positive (GP) bacteria responsible for common infections such as community-acquired pneumonia (CAP), as well as complicated infections such as bacteremia, infective endocarditis and meningitis. S. pneumoniae bacteremia ranks among the top 10 most common pathogens associated with bloodstream infections and correlates with high morbidity and mortality worldwide.

Conditions

Streptococcus Pneumoniae

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Study Overview

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Study Details

Study overview

Streptococcus pneumoniae is a gram-positive (GP) bacteria responsible for common infections such as community-acquired pneumonia (CAP), as well as complicated infections such as bacteremia, infective endocarditis and meningitis. S. pneumoniae bacteremia ranks among the top 10 most common pathogens associated with bloodstream infections and correlates with high morbidity and mortality worldwide.

Short Versus Long Duration of Therapy for Streptococcus Pneumoniae Bloodstream

Short Versus Long Duration of Therapy for Streptococcus Pneumoniae Bloodstream Infections

Condition
Streptococcus Pneumoniae
Intervention / Treatment

-

Contacts and Locations

Dallas

Methodist Dallas Medical Center, Dallas, Texas, United States, 75203

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * • ≥18 years of age
  • * S. pneumoniae isolated from ≥1 blood cultures
  • * Active IV antibiotic therapy within 48 hours of the first positive blood culture(7,8)
  • * Clinical stability by day 10 of therapy
  • * • Treatment duration \<5 days or \>16 days
  • * Death before completion of therapy (\<10 days vs. ≥ 10 days )
  • * Polymicrobial BSI
  • * Invasive infection caused by S. pneumoniae (endocarditis, meningitis, and lung abscess)

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Methodist Health System,

Matthew Crotty, PharmD, PRINCIPAL_INVESTIGATOR, Methodist Midlothian Medical Center

Study Record Dates

2024-06-23