RECRUITING

Psychotherapy Effects on Reward Processing in PTSD

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Conditions

Post Traumatic Stress DisorderDiminished PleasureAnhedoniaPTSDChronic PTSDChronic Post-Traumatic Stress DisorderPost Traumatic StressEmotional NumbingCPTCognitive Processing TherapyTherapy

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience positive emotions following a traumatic or extremely stressful life event. In this instance, the investigators will be using cognitive processing therapy (CPT), a widely-utilized and evidence-based treatment for PTSD.

Official Title

The Effects of Trauma-focused Psychotherapy on Reward Circuitry Function and Information Encoding

Quick Facts

Study Start:2024-06-01
Study Completion:2029-05-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06096740

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * English as primary language, and comprehension suitable to understand experimenter instructions.
  2. * Current and chronic syndromic PTSD, defined as being exposed to a DSM-5 Criterion A traumatic event, with the presence DSM-5 qualifying PTSD symptoms for at least 3 months, as assessed by the Clinician-Administered PTSD Scale for DSM-5.
  3. * Able and willing to undergo functional magnetic resonance imaging (fMRI).
  4. * Willingness to participate in repeated assessments and as part of a delayed treatment group.
  1. * Evidence of current or prior history of psychosis or bipolar disorder as evidenced by self-report or clinical interview.
  2. * Active substance dependence within the past 6 months as evidenced by clinical interview.
  3. * Current regular psychiatric medication use (i.e. antidepressants), except for as-needed benzodiazepine or opiate medication no more than three times per week, on average, or for short-duration stimulant medication for attention deficit hyperactivity disorder that can be skipped within 24 hours of study visits.
  4. * A recent (\<6 months) suicide attempt or current active ideation with intent.
  5. * Unremovable ferrous metal in body.
  6. * History of neurological disorder, stroke, seizures/convulsions (except febrile seizures in childhood), epilepsy, brain surgery, electroconvulsive or radiation treatment, brain hemorrhage or tumor, or thyroid disorder.
  7. * Anyone who is pregnant or trying to become pregnant.
  8. * Current or past year (\> 3 sessions), psychotherapy with a prominent exposure or cognitive restructuring component.
  9. * Previous or current (es)ketamine treatment and/ or brain stimulation/neuromodulation treatment.
  10. * Other ongoing treatment that is likely to confound experimental effects.
  11. * Previous penetrating head injury/traumatic brain injury. Mild-to-moderate traumatic brain injury without penetrating injury is allowable.

Contacts and Locations

Study Contact

Lauren Enten, B.S.A
CONTACT
512-495-5856
fonzolab@austin.utexas.edu

Principal Investigator

Gregory A Fonzo, PhD
PRINCIPAL_INVESTIGATOR
The University of Texas at Austin

Study Locations (Sites)

Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600
Austin, Texas, 78712
United States

Collaborators and Investigators

Sponsor: University of Texas at Austin

  • Gregory A Fonzo, PhD, PRINCIPAL_INVESTIGATOR, The University of Texas at Austin

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-01
Study Completion Date2029-05-01

Study Record Updates

Study Start Date2024-06-01
Study Completion Date2029-05-01

Terms related to this study

Keywords Provided by Researchers

  • PTSD
  • Post Traumatic Stress
  • Emotional Numbing
  • CPT
  • Cognitive Processing Therapy
  • Therapy
  • Chronic PTSD

Additional Relevant MeSH Terms

  • Post Traumatic Stress Disorder
  • Diminished Pleasure
  • Anhedonia
  • PTSD
  • Chronic PTSD
  • Chronic Post-Traumatic Stress Disorder