RECRUITING

MCI Speech in Noise

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine whether people with MCI (Mild Cognitive Impairment) and healthy comparison subjects differ with respect to their ability to hear soft sounds and how their brain understands and processes sound. The investigators are also evaluating, within those with MCI, whether the hearing tests are associated with neurocognitive functioning. The investigators are interested in learning whether changes in cognition in those with MCI can be detected using tests of how the brain processes sound. The investigators hypothesize that participants with MCI will score worse on both hearing tests and neurocognitive tests than participants without MCI. Participants are asked to complete multiple types of hearing tests, take a series of neurocognitive tests, and complete a few questionnaires.

Official Title

Speech Perception in Noise as an Improved Marker for Neurocognitive Dysfunction

Quick Facts

Study Start:2024-05-18
Study Completion:2025-12-02
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06102486

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults diagnosed with or suspected to have MCI (for MCI group) or are cognitively normal (for Control group)
  2. * Absence of other risk factors that might affect CAP (Central Auditory Processing) performance (e.g., active ear infections, congenital developmental delay, severe hearing loss)
  3. * Age 55-80
  4. * Normal hearing sensitivity (\<40 dB HL Pure Tone Average (average of 500, 1000, 2000 Hz) thresholds bilaterally
  5. * Normal middle ear function defined by tympanometry (0.3-2.0 ml)
  6. * Native English speaker
  1. * Active ear infections or abnormal middle ear pathology
  2. * Other health condition prohibiting the completion of the CAP test battery
  3. * Mild to profound peripheral hearing loss (\>40 dB (decibel) HL (hearing loss) Pure Tone Average (average of 500, 1000, 2000 Hz) bilaterally
  4. * Adults unable to consent
  5. * Individuals who are not yet adults (infants, children, teenagers)
  6. * Prisoners
  7. * History of CNS (Central Nervous System) disorder that might severely impact cognitive function (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, neurosyphilis, intracranial tumors, history of significant head trauma with loss of consciousness (≥30 min), and cerebrovascular disease)
  8. * Severe mental illness (e.g., schizophrenia, bipolar disorder)
  9. * Current, uncontrolled medical condition that could affect cognition (e.g., hypertension)
  10. * History of substance use disorder within the (other than nicotine/caffeine)
  11. * Non-correctable severe hearing or vision loss
  12. * Use of "Cognition Enhancing Drugs"
  13. * Frequent, severe headaches (occasional headaches or migraines are fine)

Contacts and Locations

Study Contact

Samantha Leigh, BS
CONTACT
5408195715
samantha.m.leigh@dartmouth.edu

Study Locations (Sites)

Space Medicine Lab at Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756
United States

Collaborators and Investigators

Sponsor: Dartmouth-Hitchcock Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-05-18
Study Completion Date2025-12-02

Study Record Updates

Study Start Date2024-05-18
Study Completion Date2025-12-02

Terms related to this study

Additional Relevant MeSH Terms

  • Mild Cognitive Impairment