MCI Speech in Noise

Description

The purpose of this study is to determine whether people with MCI (Mild Cognitive Impairment) and healthy comparison subjects differ with respect to their ability to hear soft sounds and how their brain understands and processes sound. The investigators are also evaluating, within those with MCI, whether the hearing tests are associated with neurocognitive functioning. The investigators are interested in learning whether changes in cognition in those with MCI can be detected using tests of how the brain processes sound. The investigators hypothesize that participants with MCI will score worse on both hearing tests and neurocognitive tests than participants without MCI. Participants are asked to complete multiple types of hearing tests, take a series of neurocognitive tests, and complete a few questionnaires.

Conditions

Mild Cognitive Impairment

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine whether people with MCI (Mild Cognitive Impairment) and healthy comparison subjects differ with respect to their ability to hear soft sounds and how their brain understands and processes sound. The investigators are also evaluating, within those with MCI, whether the hearing tests are associated with neurocognitive functioning. The investigators are interested in learning whether changes in cognition in those with MCI can be detected using tests of how the brain processes sound. The investigators hypothesize that participants with MCI will score worse on both hearing tests and neurocognitive tests than participants without MCI. Participants are asked to complete multiple types of hearing tests, take a series of neurocognitive tests, and complete a few questionnaires.

Speech Perception in Noise as an Improved Marker for Neurocognitive Dysfunction

MCI Speech in Noise

Condition
Mild Cognitive Impairment
Intervention / Treatment

-

Contacts and Locations

Lebanon

Space Medicine Lab at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States, 03756

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults diagnosed with or suspected to have MCI (for MCI group) or are cognitively normal (for Control group)
  • * Absence of other risk factors that might affect CAP (Central Auditory Processing) performance (e.g., active ear infections, congenital developmental delay, severe hearing loss)
  • * Age 55-80
  • * Normal hearing sensitivity (\<40 dB HL Pure Tone Average (average of 500, 1000, 2000 Hz) thresholds bilaterally
  • * Normal middle ear function defined by tympanometry (0.3-2.0 ml)
  • * Native English speaker
  • * Active ear infections or abnormal middle ear pathology
  • * Other health condition prohibiting the completion of the CAP test battery
  • * Mild to profound peripheral hearing loss (\>40 dB (decibel) HL (hearing loss) Pure Tone Average (average of 500, 1000, 2000 Hz) bilaterally
  • * Adults unable to consent
  • * Individuals who are not yet adults (infants, children, teenagers)
  • * Prisoners
  • * History of CNS (Central Nervous System) disorder that might severely impact cognitive function (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, neurosyphilis, intracranial tumors, history of significant head trauma with loss of consciousness (≥30 min), and cerebrovascular disease)
  • * Severe mental illness (e.g., schizophrenia, bipolar disorder)
  • * Current, uncontrolled medical condition that could affect cognition (e.g., hypertension)
  • * History of substance use disorder within the (other than nicotine/caffeine)
  • * Non-correctable severe hearing or vision loss
  • * Use of "Cognition Enhancing Drugs"
  • * Frequent, severe headaches (occasional headaches or migraines are fine)

Ages Eligible for Study

55 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Dartmouth-Hitchcock Medical Center,

Study Record Dates

2025-12-02