A Placebo-controlled Safety and Tolerability Study of Intravenous (IV) and Subcutaneous (SC) AZD1163 in Healthy Volunteers

Eligibility Criteria

• * Healthy male and female participants with suitable veins for cannulation or repeated venipuncture
• * All females must have a negative pregnancy test
• * Females of childbearing potential must not be lactating and, if heterosexually active agree to an approved method of highly effective contraception.
• * BMI between 18 and 32 kg/m\^2 and weigh at least 45 kg
• * Has received another new chemical entity
• * History of any disease or disorder which may put participant at risk in the study
• * Current or recurrent disease of clinical significance
• * Medical history of malignancies except for cervical carcinoma and non-melanoma skin cancer (NMSC)
• * Any clinically important illness, medical/procedure, or trauma
• * Any clinically important abnormalities in clinical chemistry, hematology, or urinalysis result at screening
• * Any positive result on screening for serum hepatitis B surface antigen (HbsAg), hepatitis B core antibody (HbcAb), hepatitis C virus (HCV) antibody, or human immunodeficiency virus (HIV)
• * History of latent or active tuberculosis (TB) or exposure to endemic areas
• * Evidence of active TB or untreated/inadequately/inappropriately treated for latent TB
• * Positive testing for Covid-19 prior to dosing, case of Covid-19 within 4 weeks, or long-term Covid-19-related sequelae
• * Active systemic bacterial, viral, or fungal infection within 14 days prior to dosing or presence of fever
• * Any clinically important abnormalities in rhythm, conduction, or morphology of the resting 12-lead electrocardiogram (ECG), and any clinically important abnormalities in the 12-lead ECG
• * Known or suspected history of alcohol or drug abuse or excessive intake of alcohol
• * History of severe allergy/hypersensitivity or ongoing clinically important allergy/hypersensitivity