Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

Description

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.

Conditions

Appetitive Behavior, Obesity

Study Overview

Study Details

Study overview

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.

Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

Condition
Appetitive Behavior
Intervention / Treatment

-

Contacts and Locations

Belmont

McLean Hospital, Belmont, Massachusetts, United States, 02478

Boston

Brigham and Women's Hospital, Boston, Massachusetts, United States, 02120

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy individuals aged 18 to 65
  • * BMI of 20-35.0 kg/m2
  • * Normal or corrected-to-normal vision
  • * Good general health
  • * Ability to understand and willingness to sign written informed consent document
  • * Current and/or past medical conditions
  • * Current and/or past eating disorder
  • * On a restricted diet and/or taking weight loss medication(s)
  • * History of bariatric surgery
  • * Weight fluctuation \>3% in past 3 months
  • * Recent history of illicit recreational drug abuse
  • * Current nicotine use
  • * Intellectual disability
  • * Conditions that might result in increased risks of side effects or complications from TMS or MRI

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Brigham and Women's Hospital,

Laura Holsen, PhD, PRINCIPAL_INVESTIGATOR, Brigham and Women's Hospital

Study Record Dates

2028-08