Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis

Description

The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee osteoarthritis (OA). Furthermore, we will explore relations of socioeconomic status, racial discrimination, acculturative stress, and autonomic function to exercise effects on EIH, central pain mechanisms, and knee pain. This will be a pilot randomized cross-over study where all participants undergo Day 1 (baseline assessments), Day 2 (UE or LE), and Day 3 (UE or LE).

Conditions

Knee Osteoarthritis, Knee Pain Chronic, Central Pain Syndrome

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Study Overview

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Study Details

Study overview

The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee osteoarthritis (OA). Furthermore, we will explore relations of socioeconomic status, racial discrimination, acculturative stress, and autonomic function to exercise effects on EIH, central pain mechanisms, and knee pain. This will be a pilot randomized cross-over study where all participants undergo Day 1 (baseline assessments), Day 2 (UE or LE), and Day 3 (UE or LE).

Comparing Effects of Upper Extremity Versus Lower Extremity Exercise on Exercise-Induced Hypoalgesia in People With Knee Osteoarthritis: A Pilot Cross-over Study

Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis

Condition
Knee Osteoarthritis
Intervention / Treatment

-

Contacts and Locations

El Paso

The University of Texas at El Paso, El Paso, Texas, United States, 79968

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * age ≥45
  • * activity-related knee pain
  • * either no morning joint-related stiffness or stiffness that lasts ≤ 30 minutes.
  • * knee pain at least 4 on a 0-10 pain scale
  • * knee pain as a chief complaint if having multiple pain
  • * understand English
  • * peripheral neuropathy or other sensation loss on the body sites for pain measurements (i.e., the wrist, knee, the forearm)
  • * use of medical devices electrically active (e.g., pacemaker)
  • * chronic use of opioids
  • * pregnant women
  • * serious and uncontrolled concomitant disease, including cardiovascular, nervous system, pulmonary, renal, hepatic, metabolic, hormonal, endocrine, gastrointestinal or epileptic disease
  • * rheumatoid arthritis, ankylosing spondylitis, and any neurological disorders that prevent the study procedure
  • * cognitive impairment
  • * history of a knee replacement surgery
  • * inability to perform exercise due to severe pain or other symptoms
  • * any intervention procedures for knee pain in the last 3 months

Ages Eligible for Study

45 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Texas, El Paso,

Study Record Dates

2025-10-16