Gut Microbial Metabolites of Apple Polyphenols

Description

The goal of this controlled feeding trial is to learn about the metabolism of polyphenols, a common class of compounds found in plant-based foods, by the gut microbiome. It will evaluate how differences in gut bacteria across individuals influence metabolism of polyphenols from foods, which may influence health benefits that people receive from different foods.

Conditions

Healthy, Controlled Feeding Trial

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Study Overview

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Study Details

Study overview

The goal of this controlled feeding trial is to learn about the metabolism of polyphenols, a common class of compounds found in plant-based foods, by the gut microbiome. It will evaluate how differences in gut bacteria across individuals influence metabolism of polyphenols from foods, which may influence health benefits that people receive from different foods.

Gut Microbial Metabolites Of Apple Polyphenols: Interrogating Individual Differences To Establish Functional Biomarker Utility

Gut Microbial Metabolites of Apple Polyphenols

Condition
Healthy
Intervention / Treatment

-

Contacts and Locations

College Park

Department of Nutrition and Food Science, College Park, Maryland, United States, 20742

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Completion of informed consent.
  • 2. Stated willingness to comply with all study procedures and availability for the duration of the study.
  • 3. Any gender identification, aged 18 - 45.
  • 4. BMI 18.5 - 40 kg/m\^2
  • 5. Ability to consume the intervention foods and beverages and be willing to adhere to the dietary regimen.
  • 6. Agreement to provide urine and fecal samples according to the study protocol.
  • 7. Agreement to adhere to avoid high catechin foods (tea, chocolate) for 4 weeks.
  • 8. Able to come to the study location for 8 visits according to the study schedule.
  • 9. As assessed through an initial urine screening phase, a person is eligible either on the basis of (1) the presence of a urinary marker for soy isoflavone metabolism (ODMA), or (2) as a control matched for age and gender.
  • 1. Current, regular use of antacids or acid reducers.
  • 2. Systemic antibiotic use within the past month prior to the urinary screening until completion of the dietary intervention.
  • 3. Pregnancy or lactation, within 3 months post-partum (regardless of breastfeeding) at screening or planning to become pregnant during the study duration.
  • 4. Known allergic reactions to components of the foods or beverages of the study diet (soy, wheat, dairy, peanut, tree nuts, apples, eggs) or any history of anaphylactic food allergy.
  • 5. Current diagnosis of renal, hepatic, or gastrointestinal conditions.
  • 6. History of stroke.
  • 7. Underweight (BMI \<18.5 kg/m\^2) or severe obesity (BMI \>40 kg/m\^2).
  • 8. Under 18 years or above 45 years of age.
  • 9. Unwilling or unable to participate in the controlled dietary intervention or provide urine or fecal samples.
  • 10. Has a pacemaker, implanted defibrillator, or other implanted electronic device.
  • 11. Change of body weight \>10% between screening and dietary intervention.

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Maryland, College Park,

Margaret Slavin, PhD, PRINCIPAL_INVESTIGATOR, University of Maryland, College Park

Study Record Dates

2025-06