RECRUITING

Maimonides Minocycline in Stroke Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to determine if oral Minocycline's proposed neuroprotective effects further improve the clinical outcomes, including mortality, of acute stroke patients beyond the current standard stroke care in a large scale randomized prospective open label (outcome assessor blinded) clinical trial. Participants will be randomly assigned (1:1) to take Minocycline 200mg orally every 24 hours for five days, starting within 24 hours from stroke symptoms onset, in addition to standard care or standard care alone. NIHSS (The National Institutes of Health Stroke Scale) and mRS (Modified Rankin Scale) will be collected at the time of presentation, discharge and again at 30- and 90-days post-discharge. All-cause mortality will also be obtained at 30 days and 90 days.

Official Title

Effect of Oral Minocycline on Acute Stroke Outcome: A Randomized Open Label Prospective Study

Quick Facts

Study Start:2023-11-01
Study Completion:2026-02-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06107725

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Age \>/=18
  2. 2. Acute onset neurological deficit consistent with acute ischemic stroke or on imaging consistent with acute ischemia as defined by WHO (World Health Organization) guidelines
  3. 3. Acute onset of neurological deficits with intracerebral Hemorrhage on imaging consistent with intracerebral bleed
  4. 4. The onset of symptoms less than 24 hours
  5. 5. Measurable neurological deficit using NIHSS (National Institutes of Health Stroke Scale )
  1. 1. Clinically not suspect stroke.
  2. 2. Allergic to the Tetracycline group of medications or Intolerance to Minocycline
  3. 3. Pregnancy or suspected pregnancy
  4. 4. Previous history of intolerance to minocycline
  5. 5. Acute or chronic renal failure
  6. 6. Any patients with contraindications to undergo CT/ MRI
  7. 7. Life expectancy less than one year or severe co-morbidities or comfort measure only (CMO) on admission
  8. 8. Pre-existing infectious disease requiring antibiotics
  9. 9. Inability to tolerate enteral medications/feeds
  10. 10. Patient/ family refusal

Contacts and Locations

Study Contact

Qingliang T Wang, MD., PhD
CONTACT
7182837670
QWang@maimonidesmed.org
Ilya Levin, DO
CONTACT
7182838681
Ilevin@maimonidesmed.org

Study Locations (Sites)

Maimonides Medical Center
Brooklyn, New York, 11219
United States

Collaborators and Investigators

Sponsor: Maimonides Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-11-01
Study Completion Date2026-02-01

Study Record Updates

Study Start Date2023-11-01
Study Completion Date2026-02-01

Terms related to this study

Keywords Provided by Researchers

  • Minocycline
  • Acute Stroke
  • Neuroprotection
  • Mortality
  • Morbidity
  • Ischemic stroke
  • Hemorrhagic Stroke
  • mRs (Modified Rankin Scale)
  • Clinical outcome

Additional Relevant MeSH Terms

  • Stroke, Acute
  • Ischemic Stroke
  • Hemorrhagic Stroke
  • Mortality
  • Morbidity