Cerebellar Modulation of Cognition in Psychosis

Description

The goal of this clinical trial is to learn about cognition in psychotic disorders (schizophrenia, bipolar disorder, and schizoaffective disorder). The main question it aims to answer is: Can we use magnetic stimulation to change processing speed (how quickly people can solve challenging tasks). Participants will be asked to perform cognitive tasks (problem-solving) and undergo brain scans before and after transcranial magnetic stimulation (TMS). TMS is a way to non-invasively change brain activity. Forms of TMS are FDA-approved to treat depression and obsessive compulsive disorder. In this study, we will use a different form of TMS to temporarily change brain activity to observe how that changes speed in problem-solving.

Conditions

Schizophrenia, Schizoaffective Disorder, Bipolar Disorder I, Psychosis

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to learn about cognition in psychotic disorders (schizophrenia, bipolar disorder, and schizoaffective disorder). The main question it aims to answer is: Can we use magnetic stimulation to change processing speed (how quickly people can solve challenging tasks). Participants will be asked to perform cognitive tasks (problem-solving) and undergo brain scans before and after transcranial magnetic stimulation (TMS). TMS is a way to non-invasively change brain activity. Forms of TMS are FDA-approved to treat depression and obsessive compulsive disorder. In this study, we will use a different form of TMS to temporarily change brain activity to observe how that changes speed in problem-solving.

Cerebellar Modulation of Cognition in Psychosis

Cerebellar Modulation of Cognition in Psychosis

Condition
Schizophrenia
Intervention / Treatment

-

Contacts and Locations

Belmont

McLean Hospital, Belmont, Massachusetts, United States, 02478

Boston

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age between 18-55 years
  • * Diagnosis of a psychotic disorder (i.e. schizophrenia or schizoaffective disorder or bipolar disorder type I)
  • * Must be able to read, speak and understand English
  • * Must be judged by study staff to be capable of completing the study procedures
  • * Participants will be in stable outpatient treatment with no recent (within the past 30 days) hospitalizations or changes in their medication regimens.
  • * Diagnostic and Statistical Manual 5 diagnosis of moderate substance use disorder within the past month
  • * Conditions that might result in increased risks of side effects or complications from rTMS or MRI, including:
  • * Intracranial pathology from a known genetic disorder (e.g., Neurofibromatosis 1, tuberous sclerosis) or from acquired neurologic disease (e.g. stroke, tumor), cerebral palsy, history of severe head injury, or significant dysmorphology;
  • * History of fainting spells of unknown or undetermined etiology that might constitute seizures
  • * History of multiple seizures or diagnosis of epilepsy
  • * Any progressive (e.g., neurodegenerative) neurological disorder such as multiple sclerosis or Parkinson's disease
  • * Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
  • * Metal implants (excluding dental fillings) unless cleared by the responsible covering MD (i.e. MRI compatible joint replacement)
  • * Pacemaker
  • * Implanted medication pump
  • * Vagal nerve stimulator
  • * Deep brain stimulator or transcutaneous electric nerve stimulation unit
  • * Ventriculo-peritoneal shunt
  • * Signs of increased intracranial pressure
  • * Intracranial lesion
  • * History of head injury resulting in prolonged loss of consciousness (\>15minutes) or neurological sequelae
  • * Pregnancy: All participants capable of becoming pregnant will be required to have a pregnancy test; any participant who is pregnant will not be enrolled in the study.

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mclean Hospital,

Study Record Dates

2029-12