Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

Description

The purpose of this study is to find out if performing additional Magnetic Resonance Image (MRI) scans of the subjects' brain during each week of the radiation treatment of their high-grade glioma will help improve the radiation treatment.

Conditions

Glioblastoma, Anaplastic Astrocytoma, Astrocytoma, Anaplastic Oligodendroglioma

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Study Overview

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Study Details

Study overview

The purpose of this study is to find out if performing additional Magnetic Resonance Image (MRI) scans of the subjects' brain during each week of the radiation treatment of their high-grade glioma will help improve the radiation treatment.

Adaptive Radiotherapy Based on Multi-Parametric Diffusion- and Perfusion-weighted Magnetic Resonance Imaging in Patients With Newly Diagnosed High-Grade Glioma

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

Condition
Glioblastoma
Intervention / Treatment

-

Contacts and Locations

New York

Columbia University Irving Medical Center/NYPH, New York, New York, United States, 10032

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Histopathologically proven diagnosis of glioblastoma, anaplastic astrocytoma, or anaplastic oligodendroglioma
  • * History and physical examination within 28 days prior to enrollment
  • * Karnofsky performance status 70 or greater
  • * Age 18 years or greater
  • * Negative pregnancy test for females of childbearing potential before 1st research MRI, performed in accordance to institutional guidelines.
  • * Plan to receive 59.4-60 Gy in 30-33 fractions of radiotherapy. Glioblastoma patients over 65 year-old can receive hypofractionated radiotherapy including 40 Gy in 15 fractions.
  • * Prior therapy for tumor except for biopsy or resection, including prior radiotherapy to the brain.
  • * Clinical or radiological evidence of metastatic disease outside the brain
  • * Prior malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 2 years

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Columbia University,

Tony J. Wang, MD, PRINCIPAL_INVESTIGATOR, Columbia University

Study Record Dates

2026-12-31