Impact of Negative Pressure Ventilation in Patients Hospitalized with Acute Hypercapnic Respiratory Failure

Description

The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.

Conditions

Acute Hypercapnic Respiratory Failure

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Study Overview

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Study Details

Study overview

The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.

Impact of Negative Pressure Ventilation in Patients Hospitalized with Acute Hypercapnic Respiratory Failure

Impact of Negative Pressure Ventilation in Patients Hospitalized with Acute Hypercapnic Respiratory Failure

Condition
Acute Hypercapnic Respiratory Failure
Intervention / Treatment

-

Contacts and Locations

Columbia

University of Missouri Hospitals, Columbia, Missouri, United States, 65212

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * admission diagnosis of hypercapnic respiratory failure
  • * pH between 7.20-7.35 in an ABG sample or pH between 7.16-.31 in a venous sample.
  • * age \<21
  • * Pregnant
  • * Inmate/Prisoner
  • * Contraindication for cuirass ventilator (open chest wound, flail chest, prior thoracic surgery)
  • * Chest wall defect, neuromuscular disease or diaphragmatic paralysis.
  • * BMI \>50

Ages Eligible for Study

21 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Missouri-Columbia,

Dennis Chairman, MD, PRINCIPAL_INVESTIGATOR, University of Missouri-Columbia

Study Record Dates

2025-10