Cerebellar Involvement in Cognitive Sequencing

Description

Although there is increasing recognition that the cerebellum is involved in cognition as well as motor function, the manner in which the cerebellum contributes to cognition is uncertain. One theory that might account for both motor and cognitive contributions of the cerebellum is that the cerebellum is involved in sequencing of relevant events or stimuli. Previous experiments have suggested that disruption of the cerebellum impairs the prediction of the next event in a sequence. The present experiment will examine the impact of cerebellar stimulation on brain activation during the performance of both sequence-demanding and non-sequence-demanding tasks.

Conditions

Effects of Cerebellar Stimulation on Brain Activation

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Study Overview

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Study Details

Study overview

Although there is increasing recognition that the cerebellum is involved in cognition as well as motor function, the manner in which the cerebellum contributes to cognition is uncertain. One theory that might account for both motor and cognitive contributions of the cerebellum is that the cerebellum is involved in sequencing of relevant events or stimuli. Previous experiments have suggested that disruption of the cerebellum impairs the prediction of the next event in a sequence. The present experiment will examine the impact of cerebellar stimulation on brain activation during the performance of both sequence-demanding and non-sequence-demanding tasks.

Investigation of Cerebellar Involvement in Cognitive Sequencing

Cerebellar Involvement in Cognitive Sequencing

Condition
Effects of Cerebellar Stimulation on Brain Activation
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 21205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 1) Age 18-50;
  • * 2) educational attainment of at least 8 years;
  • * 3) capable of giving informed consent;
  • * 4) fluent speaker of English by self-report;
  • * 5) right handed.
  • * 1) illicit drug use within 30 days of MRI scanning;
  • * 2) neurological or systemic disorder which can cause dementia or cognitive dysfunction;
  • * 3) history of an Axis I psychiatric disorder including substance use disorder;
  • * 4) history of definite stroke;
  • * 5) focal lesion on MRI exam;
  • * 6) uncorrected visual deficits by self-report
  • * 7) contraindications for MRI scanning
  • * 8) use of anxiolytic, antidepressant, neuroleptic, or sedative medication
  • * 9) Additional exclusion criteria recommended by Wassermann for TMS neuromodulation, including: History of seizure or a family history of epilepsy, heart disease, intracardiac lines, increased intracranial pressure, history of head trauma, and history of respiratory disease

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

John E Desmond, Ph.D., PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2027-07-31