Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

Description

The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in Veterans with a history of mild traumatic brain injury (mTBI). The study will also complete resting-state MRI scans to assess neurophysiological markers of photosensitivity and changes associated with LIP-tES intervention.

Conditions

Mild Traumatic Brain Injury, Photophobia

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Study Overview

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Study Details

Study overview

The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in Veterans with a history of mild traumatic brain injury (mTBI). The study will also complete resting-state MRI scans to assess neurophysiological markers of photosensitivity and changes associated with LIP-tES intervention.

A Novel Neurofeedback Intervention for Photosensitivity in Mild Traumatic Brain Injury

Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

Condition
Mild Traumatic Brain Injury
Intervention / Treatment

-

Contacts and Locations

Boston

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts, United States, 02130-4817

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 18-65
  • * Documented history of mTBI at least 6 months prior to initial study visit
  • * Documented symptoms of photosensitivity
  • * Eye exam within the last 12 months documenting best-corrected acuity of 20/20 or better, normal pupillary function, color vision, no abnormalities on OCT scan, and normal Humphrey Visual Field test
  • * History of strabismus or amblyopia
  • * Significant ocular media opacity that could reduce the amount of light entering the pupil in one or both eyes
  • * Previous or current history of retinal or optic nerve pathology in one or both eyes
  • * History of stroke and/or visual neglect
  • * History of neurodegenerative disease (e.g., Parkinson's, multiple sclerosis)
  • * History of epilepsy or seizures
  • * History of motor tics
  • * Current use of medications or substances that may severely affect pupillary response and/or increase photosensitivity
  • * Individuals with impaired decision-making capacity
  • * Illiterate or no English language proficiency

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Francesca C Fortenbaugh, PhD, PRINCIPAL_INVESTIGATOR, VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Study Record Dates

2025-11-30