A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Description

The purpose of this study is to evaluate the mavacamten impact on myocardial structure with cardiac magnetic resonance imaging (CMR) in adult participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) \[New York Heart Association (NYHA) Functional Class II or III\].

Conditions

Cardiomyopathy, Hypertrophic

Study Overview

Study Details

Study overview

The purpose of this study is to evaluate the mavacamten impact on myocardial structure with cardiac magnetic resonance imaging (CMR) in adult participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) \[New York Heart Association (NYHA) Functional Class II or III\].

MEMENTO - A Phase 4, Single-arm, Open-label Clinical Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy to Assess the Impact on Myocardial Structure With Cardiac Magnetic Resonance Imaging (CMR)

A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Condition
Cardiomyopathy, Hypertrophic
Intervention / Treatment

-

Contacts and Locations

West Hollywood

Local Institution - 0087, West Hollywood, California, United States, 90048-1804

Atlanta

Piedmont Hospital, Atlanta, Georgia, United States, 30309

Honolulu

Local Institution - 0091, Honolulu, Hawaii, United States, 96813-2414

Boston

Local Institution - 0093, Boston, Massachusetts, United States, 02114

Cleveland

Local Institution - 0090, Cleveland, Ohio, United States, 44106

Pittsburgh

Allegheny General Hospital, Pittsburgh, Pennsylvania, United States, 15212-4756

Houston

Houston Methodist Hospital, Houston, Texas, United States, 77030

Murray

Local Institution - 0035, Murray, Utah, United States, 84107-5701

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Bristol-Myers Squibb,

    Bristol-Myers Squibb, STUDY_DIRECTOR, Bristol-Myers Squibb

    Study Record Dates

    2026-07-31