StrokeCog-BBB to Study Cognitive Outcomes Following Stroke

Description

The goal of this observational study is to learn about cognitive outcomes in stroke patients. The main question it aims to answer are: 1. Is blood-brain barrier permeability compromised for years after stroke, 2. Is a blood biomarker of imbalanced angiogenesis dysregulated in chronic stroke and 3. Are there biomarkers that separately or together predicts cognitive decline after stroke, and are other MRI, blood, and clinical characteristics that are associated. Participants will undergo cognitive testing and MRIs two years apart. Researchers will compare cognitive outcomes in non-stroke patients who have cardiovascular risk factors to understand the effects of stroke on these outcomes.

Conditions

Stroke

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Study Overview

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Study Details

Study overview

The goal of this observational study is to learn about cognitive outcomes in stroke patients. The main question it aims to answer are: 1. Is blood-brain barrier permeability compromised for years after stroke, 2. Is a blood biomarker of imbalanced angiogenesis dysregulated in chronic stroke and 3. Are there biomarkers that separately or together predicts cognitive decline after stroke, and are other MRI, blood, and clinical characteristics that are associated. Participants will undergo cognitive testing and MRIs two years apart. Researchers will compare cognitive outcomes in non-stroke patients who have cardiovascular risk factors to understand the effects of stroke on these outcomes.

StrokeCog-BBB to Study Cognitive Outcomes Following Stroke

StrokeCog-BBB to Study Cognitive Outcomes Following Stroke

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Palo Alto

Stanford University Hospital, Palo Alto, California, United States, 94304

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged 45 years or over
  • * One or more vascular risk factors (e.g. high blood pressure, diabetes or vascular disease such as angina, a previous heart attack, a heart bypass or peripheral artery disease in the legs)
  • * Established vascular disease (previous MI, angina, vascular stent in the peripheral bed)
  • * Sufficiently fluent in written and spoken English
  • * Living independently in the community
  • * Willing/able to give consent to study participation.
  • * Current treatment with IL-1 blockade or established immune-suppressant therapy (e.g. IL-1Ra or IL-1 antibodies), or treatment within the last 3 months
  • * Currently participating in a clinical trial of investigation medicinal product (CTIMP) or device trial.
  • * No history of any previous ischaemic or haemorrhagic stroke, a mini-stroke or a serious brain injury
  • * Do not have dementia
  • * Renovascular Disease
  • * Major neurological disease (immune mediated, previous brain tumors)

Ages Eligible for Study

45 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Marion Buckwalter, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2027-12-31